抗磷脂综合征孕妇的抗体谱及低剂量阿司匹林和低分子量肝素治疗后的妊娠结局
Antibody profile of pregnant women with antiphospholipid syndrome and pregnancy outcome after treatment with low dose aspirin and low-weight-molecular heparin.
作者信息
Glasnović Marija, Bosnjak Ivica, Vcev Aleksandar, Soldo Ivan, Kosuta Maja, Lenz Bahrija, Glasnović-Horvatić Elizabeta, Soldo-Butković Silva, Mićunović Nikola
机构信息
Department of Internal Medicine, School of Medicine, University of J. J. Strossmayer, Osijek, Croatia.
出版信息
Coll Antropol. 2007 Mar;31(1):173-7.
The aim of the research was to show our diagnostic and therapeutic experience with antiphospholipid syndrome (APS) in pregnant women. 36 pregnant women suspect on APS were included in the study: 32 with primary antiphospholipd syndrome (PAPS) and 4 with secondary antiphospholipid syndrome (SAPS). All pregnant women received low-molecular-weight-heparin (LMWH) and low dose aspirin (LDA) therapy. Control group represented 26 women with SAPS and previous bad reproductive anamnesis. Average pregnancy lasted 37.06 +/- 0.707 weeks. LMWH and LDA therapy was successful in 97.22%. Lupus anticoagulant (LA) was found to be more frequent in PAPS group (71.87%). Anticardiolipin antibodies (aCL) were found to be more frequent in SAPS (26.66%). For three patients (3.37%), PAPS was diagnosed due to a fact that they had positive antibeta2-glycoproteinl (antibeta-GP1). To make APS diagnosis, it is of great importance to search for all antiphospholipid antibodies. LMWH and low dose of acetylsalicylic acid should be the first choice therapy.
该研究的目的是展示我们在孕妇抗磷脂综合征（APS）方面的诊断和治疗经验。36名疑似患有APS的孕妇被纳入研究：32例为原发性抗磷脂综合征（PAPS），4例为继发性抗磷脂综合征（SAPS）。所有孕妇均接受低分子量肝素（LMWH）和小剂量阿司匹林（LDA）治疗。对照组为26名患有SAPS且既往有不良生殖史的女性。平均妊娠持续37.06±0.707周。LMWH和LDA治疗的成功率为97.22%。狼疮抗凝物（LA）在PAPS组中更为常见（71.87%）。抗心磷脂抗体（aCL）在SAPS组中更为常见（26.66%）。有3例患者（3.37%）因抗β2糖蛋白1（抗β-GP1）呈阳性而被诊断为PAPS。要做出APS诊断，寻找所有抗磷脂抗体非常重要。LMWH和小剂量乙酰水杨酸应作为首选治疗方法。
Zotero 插件