Kotikoski Hanna, Oksala Olli, Vapaatalo Heikki, Aine Esko
Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, University of Helsinki, Finland.
Acta Ophthalmol Scand. 2003 Aug;81(4):355-60. doi: 10.1034/j.1600-0420.2003.00109.x.
To investigate whether a nitric oxide donor given as a single oral dose is able to modify aqueous humour flow in healthy volunteers.
Ten healthy volunteers participated in a randomized, double-masked and placebo-controlled cross-over study. Aqueous humour flow was assessed by fluorophotometry after intake of isosorbide-5-mononitrate (ISMN), 10 mg. Topical timolol maleate, which is known to reduce aqueous humour flow, was used as a positive control. Intraocular pressure (IOP) was measured by applanation tonometry and blood pressure was registered.
The basal rate of aqueous humour flow did not change significantly after a single oral dose of ISMN. The aqueous humour flow in the timolol-treated eye was reduced as compared to the contralateral control eye (p = 0.002). Mean IOP 6 hours after placebo and ISMN intake did not differ significantly. Timolol lowered IOP by 4 mmHg (p < 0.001). ISMN did not lower systolic blood pressure, but diastolic blood pressure was reduced by 4 mmHg (p = 0.048).
A single oral dose of 10 mg ISMN had no significant effect on aqueous humour flow in healthy volunteers.
研究单剂量口服一氧化氮供体是否能够改变健康志愿者的房水流出率。
10名健康志愿者参与了一项随机、双盲、安慰剂对照的交叉研究。在摄入10mg单硝酸异山梨酯（ISMN）后，通过荧光光度法评估房水流出率。已知可降低房水流出率的局部用马来酸噻吗洛尔用作阳性对照。通过压平眼压计测量眼压并记录血压。
单次口服ISMN后，房水流出的基础速率没有显著变化。与对侧对照眼相比，噻吗洛尔治疗眼的房水流出率降低（p = 0.002）。安慰剂和ISMN摄入后6小时的平均眼压没有显著差异。噻吗洛尔使眼压降低了4mmHg（p < 0.001）。ISMN没有降低收缩压，但舒张压降低了4mmHg（p = 0.048）。
单次口服10mg ISMN对健康志愿者的房水流出率没有显著影响。
