Alm A, Koskela T, Taarnhøj J
Department of Ophthalmology, University Hospital, Umeå, Sweden.
Acta Ophthalmol (Copenh). 1990 Feb;68(1):19-22. doi: 10.1111/j.1755-3768.1990.tb01643.x.
The effect on intraocular pressure of 0.5, 1.0, 2.0 or 4.0% D-timolol and 0.25 or 0.5% L-timolol was determined in healthy volunteers after a single topical application. A dose-response relationship for D-timolol could be established. The effect on a diurnal pressure curve and on aqueous humour production was about twice as large with 0.25% L-timolol as with 4.0% D-timolol.
单次局部应用后，在健康志愿者中测定了0.5%、1.0%、2.0%或4.0%的D - 噻吗洛尔以及0.25%或0.5%的L - 噻吗洛尔对眼压的影响。可以建立D - 噻吗洛尔的剂量 - 反应关系。0.25%的L - 噻吗洛尔对昼夜眼压曲线和房水生成的影响约为4.0%的D - 噻吗洛尔的两倍。
