抗中性粒细胞胞浆抗体阳性巩膜炎伴双侧视网膜和脉络膜联合脱离
Bilateral combined retinal and choroidal detachment in antineutrophil cytoplasmic antibody-positive scleritis.
作者信息
Matthews B Non, Stavrou Panagiota
机构信息
Birmingham and Midland Eye Centre, City Hospital NHS Trust, Birmingham B18 7QU, UK.
出版信息
Acta Ophthalmol Scand. 2003 Aug;81(4):405-7. doi: 10.1034/j.1600-0420.2003.00083.x.
PURPOSE
To describe a rare complication of scleritis in a patient with positive serum antineutrophil cytoplasmic antibodies (ANCA).
METHODS
We present a case report of a patient who developed bilateral retinal and choroidal detachment associated with ANCA-positive scleritis.
RESULTS
Oral steroids alone were insufficient to maintain sustained remission of ocular inflammation. Clinical relapse of the scleritis was associated with ANCA titres becoming positive again. A combination of cyclophosphamide and steroids was successful in achieving control of the intraocular inflammation over a follow-up period of 18 months.
CONCLUSION
Bilateral combined retinal and choroidal detachment is a potentially blinding complication of ANCA-positive scleritis. Monitoring of ANCA titres is useful in the management of the disease.
目的
描述血清抗中性粒细胞胞浆抗体（ANCA）阳性患者巩膜炎的一种罕见并发症。
方法
我们报告一例发生双侧视网膜和脉络膜脱离且与ANCA阳性巩膜炎相关的患者。
结果
单独口服类固醇不足以维持眼部炎症的持续缓解。巩膜炎的临床复发与ANCA滴度再次转为阳性有关。环磷酰胺和类固醇联合使用成功控制了18个月随访期内的眼内炎症。
结论
双侧视网膜和脉络膜联合脱离是ANCA阳性巩膜炎的一种潜在致盲并发症。监测ANCA滴度对该病的管理有用。
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