Van Rijswijk J B, Boeke E L, Keizer J M, Mulder P G H, Blom H M, Fokkens W J
Department of Otorhinolaryngology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Allergy. 2003 Aug;58(8):754-61. doi: 10.1034/j.1398-9995.2003.00203.x.
In a recent study, we showed that intranasal capsaicin spray gives a significant and long-term reduction of symptoms in nonallergic noninfectious perennial rhinitis patients. However, in daily practice, the studied application regimen proved to be impractical because of the large number of visits required in a short period of time. In the present study, we conducted a double-blind double-dummy parallel groups trial to determine whether a more practical capsaicin application schedule is equally effective.
Thirty patients were randomized into two different treatment regimens: one group received capsaicin five times on the first day at 1-h intervals. This was followed by a placebo dummy once every second or third day for a total of five treatments 2 weeks after the capsaicin application (group A). The other group (B) received the placebo dummy five times on the first day followed by capsaicin once every second or third day for a total of five treatments 2 weeks after the placebo application.
The visual analogue scale scores for overall nasal symptoms, rhinorrhea and nasal blockage showed significant decrease after the start of treatment in both groups, with a significantly steeper decrease in group A. A significant reduction in cold dry air dose responsiveness was also found up to 9 months after therapy in both groups, reflecting a decrease in nasal hyperreactivity. No significant changes in safety data (smell, blood pressure, heart rate) were found.
We conclude that intranasal capsaicin seems safe to use and that five treatments of capsaicin on a single day is at least as effective as five treatments of capsaicin in 2 weeks.
在最近的一项研究中，我们发现鼻内注射辣椒素喷雾剂能显著且长期减轻非过敏性非感染性常年性鼻炎患者的症状。然而，在日常实践中，由于短期内需要多次就诊，所研究的应用方案被证明不切实际。在本研究中，我们进行了一项双盲双模拟平行组试验，以确定更实用的辣椒素应用方案是否同样有效。
30名患者被随机分为两种不同的治疗方案：一组在第一天每隔1小时接受5次辣椒素治疗。随后，在应用辣椒素2周后，每隔第二天或第三天接受一次安慰剂模拟治疗，共进行5次治疗（A组）。另一组（B组）在第一天接受5次安慰剂模拟治疗，随后在应用安慰剂2周后每隔第二天或第三天接受一次辣椒素治疗，共进行5次治疗。
两组治疗开始后，总体鼻部症状、流涕和鼻塞的视觉模拟量表评分均显著下降，A组下降更为显著。两组在治疗后长达9个月时，冷干空气剂量反应性也显著降低，反映出鼻高反应性降低。安全性数据（嗅觉、血压、心率）未发现显著变化。
我们得出结论，鼻内使用辣椒素似乎是安全的，且一天内进行5次辣椒素治疗至少与2周内进行5次辣椒素治疗效果相同。
