Raphael K Regi, Kuttan Ramadasan
Amala Cancer Research Centre, Thrissur, Kerala 680 553, India.
J Ethnopharmacol. 2003 Aug;87(2-3):193-7. doi: 10.1016/s0378-8741(03)00120-x.
Methanolic extract of Phyllanthus amarus Shum & Thonn (Euphorbiaceae) 50, 200, and 1000 mg/kg body weight significantly inhibited gastric lesions, induced by intragastric administration of absolute ethanol (8 ml/kg). Mortality, increased stomach weight, ulcer index, and intraluminal bleeding were reduced significantly by Phyllanthus amarus. Biochemical analysis indicated that reduced glutathione (GSH) of gastric mucosa produced by ethanol administration was significantly elevated by treatment with Phyllanthus amarus extract. Aqueous and methanol extracts of Phyllanthus amarus produced an inhibition of rat paw edema up to 42% compared to control in 3h and continued up to 8h. Anti-oxidant activity of the extract as well as presence of tannins in the extract may be responsible for these observed activities.
苦味叶下珠（大戟科）的甲醇提取物，剂量为50、200和1000毫克/千克体重时，可显著抑制由灌胃给予无水乙醇（8毫升/千克）诱导的胃损伤。苦味叶下珠可显著降低死亡率、胃重量增加、溃疡指数和腔内出血。生化分析表明，用苦味叶下珠提取物处理可显著提高因给予乙醇而产生的胃黏膜还原型谷胱甘肽（GSH）水平。与对照组相比，苦味叶下珠的水提取物和甲醇提取物在3小时内对大鼠足爪水肿的抑制率高达42%，并持续至8小时。提取物的抗氧化活性以及提取物中存在的单宁可能是导致这些观察到的活性的原因。
