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Schum. & Thonn.及其化合物抗过敏活性的机制研究。

Mechanistic Studies of the Antiallergic Activity of Schum. & Thonn. and Its Compounds.

机构信息

Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.

Horticulture Research Centre, Malaysian Agricultural Research and Development Institute (MARDI), P.O. Box 12301, Kuala Lumpur 50774, Malaysia.

出版信息

Molecules. 2021 Jan 28;26(3):695. doi: 10.3390/molecules26030695.

DOI:10.3390/molecules26030695
PMID:33525733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7865555/
Abstract

Schum. & Thonn. (Phyllanthaceae) is a medicinal plant that is commonly used to treat diseases such as asthma, diabetes, and anemia. This study aimed to examine the antiallergic activity of extract and its compounds. The antiallergic activity was determined by measuring the concentration of allergy markers release from rat basophilic leukemia (RBL-2H3) cells with ketotifen fumarate as the positive control. As a result, did not stabilize mast cell degranulation but exhibited antihistamine activity. The antihistamine activity was evaluated by conducting a competition radioligand binding assay on the histamine 1 receptor (H1R). Four compounds were identified from the high performance liquid chromatography (HPLC) analysis which were phyllanthin (1), hypophyllanthin (2), niranthin (3), and corilagin (4). To gain insights into the binding interactions of the most active compound hypophyllanthin (2), molecular docking was conducted and found that hypophyllanthin (2) exhibited favorable binding in the H1R binding site. In conclusion, P. amarus and hypophyllanthin (2) could potentially exhibit antiallergic activity by preventing the activation of the H1 receptor.

摘要

舒姆和托恩（叶下珠科）是一种药用植物，常用于治疗哮喘、糖尿病和贫血等疾病。本研究旨在研究 提取物及其化合物的抗过敏活性。通过用富马酸酮替芬作为阳性对照来测量从大鼠嗜碱性白血病（RBL-2H3）细胞释放的过敏标志物的浓度来确定抗过敏活性。结果表明， 没有稳定肥大细胞脱颗粒，但表现出抗组胺活性。通过组胺 1 受体（H1R）的竞争放射配体结合测定评估抗组胺活性。从高效液相色谱（HPLC）分析中鉴定出 4 种化合物，分别为叶下珠素（1）、隐叶下珠素（2）、新叶下珠素（3）和柯里拉京（4）。为了深入了解最活跃的化合物隐叶下珠素（2）的结合相互作用，进行了分子对接，发现隐叶下珠素（2）在 H1R 结合位点表现出良好的结合。总之，P. amarus 和隐叶下珠素（2）可能通过防止 H1 受体的激活来表现出抗过敏活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/41b7c006d66d/molecules-26-00695-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/d05102d83061/molecules-26-00695-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/4827906a95a6/molecules-26-00695-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/204cecbee1f7/molecules-26-00695-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/6579efcf7902/molecules-26-00695-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/f97b6662b642/molecules-26-00695-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/e28b7bc18b1f/molecules-26-00695-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/41b7c006d66d/molecules-26-00695-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/d05102d83061/molecules-26-00695-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/4827906a95a6/molecules-26-00695-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/204cecbee1f7/molecules-26-00695-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/6579efcf7902/molecules-26-00695-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/f97b6662b642/molecules-26-00695-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/e28b7bc18b1f/molecules-26-00695-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f38/7865555/41b7c006d66d/molecules-26-00695-g007.jpg

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1
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BMC Complement Altern Med. 2019 Dec 11;19(1):361. doi: 10.1186/s12906-019-2776-1.
2
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Immunopharmacol Immunotoxicol. 2019 Feb;41(1):55-67. doi: 10.1080/08923973.2018.1545788. Epub 2018 Dec 12.
3
Phyllanthin from Phyllanthus amarus inhibits cellular and humoral immune responses in Balb/C mice.
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Nucleus (Calcutta). 2022;65(3):437-472. doi: 10.1007/s13237-022-00409-z. Epub 2022 Nov 12.
4
Hydrolyzable Tannins in the Management of Th1, Th2 and Th17 Inflammatory-Related Diseases.水解单宁在 Th1、Th2 和 Th17 炎症相关疾病治疗中的作用
Molecules. 2022 Nov 5;27(21):7593. doi: 10.3390/molecules27217593.
苦味叶下珠中的叶下珠素抑制Balb/C小鼠的细胞免疫和体液免疫反应。
Phytomedicine. 2016 Nov 15;23(12):1441-1450. doi: 10.1016/j.phymed.2016.08.002. Epub 2016 Aug 17.
4
Does β-hexosaminidase function only as a degranulation indicator in mast cells? The primary role of β-hexosaminidase in mast cell granules.β-己糖胺酶是否仅作为肥大细胞脱颗粒的指标？β-己糖胺酶在肥大细胞颗粒中的主要作用。
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5
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8
Chromatographic fingerprint and the simultaneous determination of five bioactive components of geranium carolinianum L. water extract by high performance liquid chromatography.卡罗莱纳老鹳草水提取物的色谱指纹图谱及高效液相色谱法同时测定其五种生物活性成分
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9
Phyllanthus species for chronic hepatitis B virus infection.用于慢性乙型肝炎病毒感染的叶下珠属植物。
Cochrane Database Syst Rev. 2011 Apr 13(4):CD008960. doi: 10.1002/14651858.CD008960.pub2.
10
Determination of four lignans in Phyllanthus niruri L. by a simple high-performance liquid chromatography method with fluorescence detection.采用简单的高效液相色谱荧光检测法测定叶下珠中四种木脂素的含量。
J Chromatogr A. 2007 Jun 22;1154(1-2):198-204. doi: 10.1016/j.chroma.2007.03.079. Epub 2007 Mar 28.