Debby Abraham, Golan Abraham, Sagiv Ron, Sadan Oscar, Glezerman Marek
Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon 58100, Israel.
Eur J Obstet Gynecol Reprod Biol. 2003 Aug 15;109(2):177-80. doi: 10.1016/s0301-2115(03)00121-0.
To investigate whether extraamniotic prostaglandin E2 (PGE2) for midtrimester pregnancy interruption in women with a scarred uterus has any adverse effects compared to those without an uterine scar.
Two hundred and sixty-two women who underwent second trimester (16-27 gestational weeks) termination of pregnancy were enrolled in this study. Thirty-one women with a uterine scar were compared with 231 patients without a scarred uterus. Extraamniotic PGE2 was applied in serial doses of 200 mcg every 2 h up to 20 doses. Intravenous infusion of oxytocin was added in cases when the fetus was not expelled. Curettage was performed in the majority of the patients.
The two groups were similar for indications for pregnancy termination, maternal age and gestational age. Gravidity and parity were significantly higher in the group with an uterine scar. The mean induction to abortion time and the complication rate were similar in both groups. No uterine rupture was observed.
Extraamniotic PGE2 for midtrimester termination of pregnancy is a safe procedure with a low complication rate, even in patients with an uterine scar.
探讨与无子宫瘢痕的女性相比，羊膜外前列腺素E2（PGE2）用于瘢痕子宫女性中期妊娠终止是否有任何不良影响。
本研究纳入了262例接受中期（妊娠16 - 27周）妊娠终止的女性。将31例有子宫瘢痕的女性与231例无子宫瘢痕的患者进行比较。羊膜外PGE2以每2小时200 mcg的连续剂量给药，直至20剂。若胎儿未排出，则加用静脉滴注缩宫素。大多数患者进行了刮宫术。
两组在妊娠终止指征、产妇年龄和孕周方面相似。有子宫瘢痕组的孕次和产次显著更高。两组的平均引产至流产时间和并发症发生率相似。未观察到子宫破裂。
即使对于有子宫瘢痕的患者，羊膜外PGE2用于中期妊娠终止也是一种并发症发生率低的安全方法。
