Numahara T, Nakagawa T, Takaiwa T
Department of Dermatology, Kagawa Medical School, Japan.
J Dermatol Sci. 1992 Nov;4(3):202-7. doi: 10.1016/0923-1811(92)90020-c.
Two mathematical indexes, Hopkins-Skellam index (HSI) and Morisita index (MI), were applied to assess the distribution of ATPase-stained epidermal Langerhans cells (ELC) in the guinea pig skin. To our knowledge, this is the first report in which the degree of regularity has been expressed numerically by computation based on theoretical equations. The regularity of ELC in the normal skin was confirmed by the value of HSI (P < 0.0001). In the topical steroid applied skin, the number of ELC decreased significantly but the value of HSI was similar to that of the normal skin; while in the ultraviolet B (UVB) exposed skin, both number of ELC and regularity of ELC distribution decreased significantly. The graph of MI for the UVB exposed skin clearly showed that the distribution of ELC had local clumps. The two indexes, HSI and MI have been quite useful for determining the regularity of ELC. These indexes may have a wide application to other cells.
应用两个数学指标，霍普金斯 - 斯克莱姆指数（HSI）和森下指数（MI），来评估豚鼠皮肤中ATP酶染色的表皮朗格汉斯细胞（ELC）的分布。据我们所知，这是第一份通过基于理论方程的计算以数值形式表达规则程度的报告。正常皮肤中ELC的规则性通过HSI值得到证实（P < 0.0001）。在局部应用类固醇的皮肤中，ELC的数量显著减少，但HSI值与正常皮肤相似；而在暴露于紫外线B（UVB）的皮肤中，ELC的数量和ELC分布的规则性均显著降低。UVB暴露皮肤的MI图清楚地表明ELC的分布有局部聚集。HSI和MI这两个指标对于确定ELC的规则性非常有用。这些指标可能在其他细胞中有广泛应用。
