Kanokmedhakul Somdej, Kanokmedhakul Kwanjai, Prajuabsuk Thirada, Soytong Kasem, Kongsaeree Palangpon, Suksamrarn Apichart
Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
Planta Med. 2003 Jun;69(6):568-71. doi: 10.1055/s-2003-40639.
A new lanostane-type triterpenoid, (20 S,22 S,23 E)-22- O-acetyl-25-hydroxylanosta-8,23( E)-dien-3-one ( 1), isolated as a new natural product for the first time, methyl 4,4'-dimethoxyvulpinate ( 2), together with the known compound 4,4'-dimethoxyvulpinic acid ( 3) were isolated from the mushroom Scleroderma citrinum. Their structures were determined using spectroscopic and chemical methods, and an X-ray analysis was performed to confirm structure of 1. Compound 1 exhibited significant antiviral activity against Herpes simplex type 1. Compound 3 and two of its derivatives, the dibromo derivative 5 and acetate derivative 6, exhibited activity towards Mycobacterium tuberculosis. In addition, 5 and 6 also showed cytotoxicity against the NCI-H187 cell line.
一种新的羊毛甾烷型三萜化合物，(20S,22S,23E)-22-O-乙酰基-25-羟基羊毛甾-8,23(E)-二烯-3-酮(1)，首次作为一种新的天然产物被分离出来，4,4'-二甲氧基狐茅素甲酯(2)，以及已知化合物4,4'-二甲氧基狐茅素酸(3)，是从蘑菇黄硬皮马勃中分离得到的。使用光谱和化学方法确定了它们的结构，并进行了X射线分析以确认1的结构。化合物1对单纯疱疹病毒1型表现出显著的抗病毒活性。化合物3及其两种衍生物，二溴衍生物5和乙酸酯衍生物6，对结核分枝杆菌表现出活性。此外，5和6对NCI-H187细胞系也显示出细胞毒性。
