来自蘑菇橙黄硬皮马勃的一种生物活性三萜类化合物及狐衣酸衍生物。

A bioactive triterpenoid and vulpinic acid derivatives from the mushroom Scleroderma citrinum.

作者信息

Kanokmedhakul Somdej, Kanokmedhakul Kwanjai, Prajuabsuk Thirada, Soytong Kasem, Kongsaeree Palangpon, Suksamrarn Apichart

机构信息

Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.

出版信息

Planta Med. 2003 Jun;69(6):568-71. doi: 10.1055/s-2003-40639.

DOI:10.1055/s-2003-40639

PMID:12865983

Abstract

A new lanostane-type triterpenoid, (20 S,22 S,23 E)-22- O-acetyl-25-hydroxylanosta-8,23( E)-dien-3-one ( 1), isolated as a new natural product for the first time, methyl 4,4'-dimethoxyvulpinate ( 2), together with the known compound 4,4'-dimethoxyvulpinic acid ( 3) were isolated from the mushroom Scleroderma citrinum. Their structures were determined using spectroscopic and chemical methods, and an X-ray analysis was performed to confirm structure of 1. Compound 1 exhibited significant antiviral activity against Herpes simplex type 1. Compound 3 and two of its derivatives, the dibromo derivative 5 and acetate derivative 6, exhibited activity towards Mycobacterium tuberculosis. In addition, 5 and 6 also showed cytotoxicity against the NCI-H187 cell line.

摘要

一种新的羊毛甾烷型三萜化合物，(20S,22S,23E)-22-O-乙酰基-25-羟基羊毛甾-8,23(E)-二烯-3-酮(1)，首次作为一种新的天然产物被分离出来，4,4'-二甲氧基狐茅素甲酯(2)，以及已知化合物4,4'-二甲氧基狐茅素酸(3)，是从蘑菇黄硬皮马勃中分离得到的。使用光谱和化学方法确定了它们的结构，并进行了X射线分析以确认1的结构。化合物1对单纯疱疹病毒1型表现出显著的抗病毒活性。化合物3及其两种衍生物，二溴衍生物5和乙酸酯衍生物6，对结核分枝杆菌表现出活性。此外，5和6对NCI-H187细胞系也显示出细胞毒性。