Weisberger James, Cornfield Dennis, Gorczyca Wojciech, Liu Zach
Division of Hematopathology, IMPATH, New York, NY, USA.
Am J Clin Pathol. 2003 Jul;120(1):49-55. doi: 10.1309/VC7M-24UC-5VG7-EUEC.
Multiparameter flow cytometric analysis was performed on the peripheral blood samples from 25 patients with acute infectious mononucleosis. Phenotypic results were matched with those for patients without viral symptomatology. Samples from all patients with infectious mononucleosis exhibited an activated (HLA-DR+, CD38+) CD8+ cytotoxic-suppressor T-cell population with aberrant down-regulation of CD7, and samples from 2 (8%) of 25 patients also showed down-regulation of CD5. The CD8+ cells also were slightly larger than normal T cells by forward scatter characteristics. None of the control samples showed down-regulation of either antigen. Aberrant pan-T-cell antigenic expression is a criterion in the immunophenotypic diagnosis of T-cell lymphoproliferative disorders. Acute Epstein-Barr virus infection should be considered in the differential diagnosis when down-regulation of CD7 is present, especially in conjunction with an activated CD8+ T-cell population.
对25例急性传染性单核细胞增多症患者的外周血样本进行了多参数流式细胞术分析。将表型结果与无病毒症状患者的结果进行匹配。所有传染性单核细胞增多症患者的样本均显示出活化的（HLA-DR+、CD38+）CD8+细胞毒性抑制性T细胞群，伴有CD7异常下调，25例患者中有2例（8%）的样本还显示CD5下调。通过前向散射特征，CD8+细胞也比正常T细胞略大。对照样本均未显示任何一种抗原的下调。异常的全T细胞抗原表达是T细胞淋巴增殖性疾病免疫表型诊断的一个标准。当存在CD7下调时，尤其是与活化的CD8+T细胞群同时出现时，鉴别诊断应考虑急性爱泼斯坦-巴尔病毒感染。
