de Paoli P, Gennari D, Reitano M, Martelli P, Sacilotto C, Comoretto R, Santini G
Microbiology Immunology, Department General Hospital, Pordenone, Italy.
Allergol Immunopathol (Madr). 1991 Mar-Apr;19(2):95-7.
The expression of phenotypic markers on CD4 and CD8 lymphocytes during the acute and convalescent phases of Epstein Barr virus (EBV) induced infectious mononucleosis was examined by two colour flow cytometry. Activated CD8 cells constitute the major population increased during acute infectious mononucleosis; in this phase we observed a preferential expansion of the CD8 CD29+ compared to the CD8 CD45RA+ cells. Serum soluble CD8 levels were also raised during the acute phase and a correlation with CD8 CD38+ and CD8 CD29+ cell numbers was found. The convalescent phase of infectious mononucleosis was characterized by a progressive return of CD8 subset and of soluble CD8 to baseline normal values. These results demonstrate that acute EBV infection induces the expansion of a CD8 subset with peculiar surface antigenic profile.
采用双色流式细胞术检测了爱泼斯坦-巴尔病毒（EBV）诱导的传染性单核细胞增多症急性期和恢复期CD4和CD8淋巴细胞表型标志物的表达。活化的CD8细胞是急性传染性单核细胞增多症期间增加的主要细胞群；在此阶段，我们观察到与CD8 CD45RA+细胞相比，CD8 CD29+细胞优先扩增。急性期血清可溶性CD8水平也升高，并且发现其与CD8 CD38+和CD8 CD29+细胞数量相关。传染性单核细胞增多症恢复期的特征是CD8亚群和可溶性CD8逐渐恢复至基线正常值。这些结果表明，急性EBV感染可诱导具有特殊表面抗原谱的CD8亚群扩增。
