Glueck Charles J, Goldenberg Naila, Streicher Patricia, Wang Ping
Jewish Hospital Cholesterol Center, ABC Building, 3200 Burnet Avenue, Cincinnati, OH 45229, USA.
Curr Diab Rep. 2003 Aug;3(4):303-12. doi: 10.1007/s11892-003-0022-0.
Pregnancy increases requirements for insulin secretion, increasing insulin resistance and demands on pancreatic b cells, promoting development of gestational diabetes (GD), particularly in women with preexisting insulin resistance, commonly in women with polycystic ovary syndrome. Preliminary studies suggest that metformin may have the unique potential to prevent the development of GD. We postulate that interventions that reduce insulin resistance and lower requirements for endogenous insulin secretion can preserve b-cell function and prevent the development of type 2 diabetes mellitus.
怀孕会增加胰岛素分泌的需求，增加胰岛素抵抗以及对胰腺β细胞的需求，从而促进妊娠期糖尿病（GD）的发展，尤其是在已有胰岛素抵抗的女性中，常见于多囊卵巢综合征患者。初步研究表明，二甲双胍可能具有预防GD发展的独特潜力。我们推测，降低胰岛素抵抗和降低内源性胰岛素分泌需求的干预措施可以维持β细胞功能并预防2型糖尿病的发生。
