Zhu Anna, Zhu Wanpeng, Wu Zhuo, Jing Yifeng
Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China.
Water Res. 2003 Sep;37(15):3718-32. doi: 10.1016/S0043-1354(03)00250-1.
Experiments were carried out on clindamycin's separation and recovery from clindamycin fermentation wastewater with nanofiltration (NF) membranes. Four types of flat-sheet NF membranes, DLNF-1, NTR-7250, XCNF-1 and MPF-44, were tested under different dynamic operating conditions. It was found that the operating pressure and solute concentration had great influence on membrane performance while flow rates (or velocities) had little influence on membrane performance. Experiments on SO4(2-) rejection were conducted with such four flat-sheet NF membranes because SO4(2-) had bad influence on microbes in biochemical process following the NF process. The results indicated that DLNF-1 and MPF-44 membranes had higher SO4(2-) rejection among four membranes. Two spiral membranes, MPS-44 (1.4 m2) and DLNF2-30 (0.24 m2), were adopted in a concentrating process for clindamycin's separation and recovery from clindamycin fermentation wastewater under laboratory conditions. After being operated for 60h, clindamycin wastewater was concentrated from 266 to 26L, and the clindamycin was concentrated from 220 to 1940 mg/L, which met the demand of reuse. This research may widen the application of NF membranes in disposal of pharmaceutical wastewater.
开展了用纳滤（NF）膜从克林霉素发酵废水中分离回收克林霉素的实验。对四种平板纳滤膜DLNF - 1、NTR - 7250、XCNF - 1和MPF - 44在不同动态操作条件下进行了测试。发现操作压力和溶质浓度对膜性能有很大影响，而流速（或速度）对膜性能影响很小。由于SO4(2-)对纳滤过程后的生化过程中的微生物有不良影响，因此用这四种平板纳滤膜进行了SO4(2-)截留实验。结果表明，DLNF - 1和MPF - 44膜在四种膜中具有较高的SO4(2-)截留率。在实验室条件下，采用两种卷式膜MPS - 44（1.4 m2）和DLNF2 - 30（0.24 m2）从克林霉素发酵废水中分离回收克林霉素。运行60小时后，克林霉素废水从266L浓缩至26L，克林霉素从220mg/L浓缩至1940mg/L，满足回用要求。本研究可能会拓宽纳滤膜在制药废水处理中的应用。
