Yoshimura Toshihiro, Chowdhury Ferdous Ara, Yoshimura Michihiro, Okamura Hitoshi
Department of Obstetrics and Gynecology, Kumamoto University School of Medicine, Honjo 1-1-1, Kumamoto 860-8556, Japan.
Gynecol Obstet Invest. 2003;56(1):10-3. doi: 10.1159/000072324. Epub 2003 Jul 14.
We recently identified a missense variant (Glu298Asp) within exon 7 of the endothelial nitric oxide synthase (eNOS) gene that is associated with severe preeclampsia in the Japanese population. Our objective was to analyze the association between the Glu298Asp eNOS gene variant and severe preeclampsia in a developing country where the incidence of preeclampsia is more frequent.
The study included 112 Bangladeshi women exhibiting severe preeclampsia and 119 control subjects. Screening for the Glu298Asp eNOS gene variant was carried out by analysis of the polymerase chain reaction-restriction fragment length polymorphism.
The analysis revealed that the frequencies of the Glu298Asp variant (Glu298Asp homozygotes and heterozygotes) in the preeclampsia (n = 40; 35%) and control (n = 42; 35%) groups were not significantly (p > 0.05) different.
We conclude that the presence of the Glu298Asp eNOS gene is not a marker for the increased risk of preeclampsia in a population where the level of prenatal care is such that preeclampsia is still frequently seen.
我们最近在内皮型一氧化氮合酶（eNOS）基因的第7外显子中鉴定出一种错义变异（Glu298Asp），该变异与日本人群中的重度子痫前期相关。我们的目的是在一个子痫前期发病率更高的发展中国家，分析Glu298Asp eNOS基因变异与重度子痫前期之间的关联。
该研究纳入了112名患有重度子痫前期的孟加拉国女性和119名对照受试者。通过聚合酶链反应-限制性片段长度多态性分析对Glu298Asp eNOS基因变异进行筛查。
分析显示，子痫前期组（n = 40；35%）和对照组（n = 42；35%）中Glu298Asp变异（Glu298Asp纯合子和杂合子）的频率无显著差异（p > 0.05）。
我们得出结论，在产前护理水平导致子痫前期仍频繁出现的人群中，Glu298Asp eNOS基因的存在并非子痫前期风险增加的标志物。
