Chen Li-Kuei, Huang Chi-Hsiang, Yeh Heui-Ming, Lee Chien-Nan, Shyu Ming-Kwang, Hsieh Fon-Jou, Lai Ling-Ping, Sun Wei-Zen
Department of Anesthesiology, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan.
Reprod Sci. 2007 Feb;14(2):175-81. doi: 10.1177/1933719107299570.
The association between the endothelial nitric oxide synthase (eNOS) gene with vascular diseases in Western populations and with severe preeclampsia (PE) in the Japanese population have been demonstrated, lacing the data in Chinese population. The authors examine the association between PE and 2 polymorphisms of the eNOS gene in a Chinese population, consisting of 92 pregnant women with PE and 256 healthy controls. All were genotyped for the Glu298Asp polymorphism in exon 7 and the number of 27 base pair repeats in intron 4 of the eNOS gene. The frequencies of both the variant T allele and eNOS 4a (small allele with 4 repeats of 27 bp) were significantly lower in the PE group than in the control group. The genotype distribution of Glu298Glu, Glu298Asp, and Asp298Asp in eNOS exon 7 and bb type and ab type in eNOS intron 4 revealed statistically significant differences between control and PE groups. This is the first study to evaluate the association between 2 polymorphisms in the maternal eNOS gene with PE simultaneously in a Chinese population. Similar to the findings in Western populations, polymorphisms in the eNOS gene may be protective against PE in a Chinese population, in contrast to the results in the Japanese population.
内皮型一氧化氮合酶（eNOS）基因与西方人群血管疾病以及日本人群重度子痫前期（PE）之间的关联已得到证实，但中国人群相关数据尚缺。作者在中国人群中研究了PE与eNOS基因2种多态性之间的关联，该人群包括92例患PE的孕妇和256例健康对照。所有研究对象均进行了eNOS基因第7外显子Glu298Asp多态性以及第4内含子27个碱基对重复序列数目的基因分型。PE组中变异型T等位基因和eNOS 4a（27 bp重复4次的小等位基因）的频率均显著低于对照组。eNOS第7外显子中Glu298Glu、Glu298Asp和Asp298Asp的基因型分布以及eNOS第4内含子中bb型和ab型在对照组和PE组之间存在统计学显著差异。这是首次在中国人群中同时评估母亲eNOS基因2种多态性与PE之间关联的研究。与西方人群的研究结果相似，eNOS基因多态性在中国人群中可能对PE具有保护作用，这与日本人群的结果相反。
