Pappa Kalliopi I, Roubelakis Maria, Vlachos George, Marinopoulos Spyros, Zissou Antonia, Anagnou Nicholas P, Antsaklis Aris
First Department of Obstetrics and Gynecology, University of Athens School of Medicine, Alexandra University Hospital, Athens, Greece.
J Matern Fetal Neonatal Med. 2011 Apr;24(4):628-35. doi: 10.3109/14767058.2010.511351. Epub 2010 Sep 14.
To evaluate the maternal, paternal, and fetal genotype contribution to preeclampsia. STUDY DESIGN, MATERIALS, AND METHODS: We combined the analysis of polymorphisms of the GSTP1, eNOS, and LPL genes - affecting biotransformation enzymes and endothelial function - in a cohort of 167 preeclamptic and normal control trios (mother, father, and child) comprising a total of 501 samples in the Greek population, never analyzed before by this approach.
For the frequency of the GSTP1 Ile(105)/Val(105), the eNOS Glu298Asp and the LPL-93 polymorphisms, statistically significant differences were found between the two groups. However, the transmission rates of the parental alleles to neonates studied by the transmission disequilibrium test, disclosed no increased rate of transmission to preeclampsia children for the variant alleles of Val(105) GSTP1, 298Asp eNOS, and -93G LPL.
These novel data, suggest that interaction of all three types of genotypes (mother, father and neonate), reveals no effects on the development of preeclampsia, but provide the impetus for further studies to decipher the individual contribution of each genetic parameter of preeclampsia.
评估母亲、父亲和胎儿的基因型对先兆子痫的影响。
研究设计、材料与方法：我们对希腊人群中167对先兆子痫患者与正常对照的三联体（母亲、父亲和孩子）进行了谷胱甘肽S-转移酶P1（GSTP1）、内皮型一氧化氮合酶（eNOS）和脂蛋白脂肪酶（LPL）基因多态性分析，这些基因影响生物转化酶和内皮功能，此前从未采用这种方法对该人群进行过分析，共涉及501个样本。
对于GSTP1 Ile(105)/Val(105)、eNOS Glu298Asp和LPL - 93多态性的频率，两组之间存在统计学显著差异。然而，通过传递不平衡检验研究亲代等位基因向新生儿的传递率时，发现GSTP1的Val(105)、eNOS的298Asp和LPL的 - 93G变异等位基因向先兆子痫患儿的传递率并未增加。
这些新数据表明，三种基因型（母亲、父亲和新生儿）之间的相互作用对先兆子痫的发生没有影响，但为进一步研究解读先兆子痫各遗传参数的个体作用提供了动力。
