Karbowski M, Youle R J
The Biochemistry Section, SNB, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Cell Death Differ. 2003 Aug;10(8):870-80. doi: 10.1038/sj.cdd.4401260.
Mitochondria exist as dynamic networks that often change shape and subcellular distribution. The number and morphology of mitochondria within a cell are controlled by precisely regulated rates of organelle fusion and fission. Recent reports have described dramatic alterations in mitochondrial morphology during the early stages of apoptotic cell death, a fragmentation of the network and the remodeling of the cristae. Surprisingly, proteins discovered to control mitochondrial morphology appear to also participate in apoptosis and proteins associated with the regulation of apoptosis have been shown to affect mitochondrial ultrastructure. In this review the recent progress in understanding the mechanisms governing mitochondrial morphology and the latest advances connecting the regulation of mitochondrial morphology with programmed cell death are discussed.
线粒体以动态网络的形式存在，其形态和亚细胞分布常常发生变化。细胞内线粒体的数量和形态由细胞器融合与分裂的精确调控速率控制。最近的报道描述了凋亡细胞死亡早期线粒体形态的显著改变，即网络的碎片化和嵴的重塑。令人惊讶的是，被发现控制线粒体形态的蛋白质似乎也参与了凋亡过程，而与凋亡调控相关的蛋白质也已被证明会影响线粒体超微结构。在这篇综述中，我们将讨论在理解线粒体形态调控机制方面的最新进展，以及将线粒体形态调控与程序性细胞死亡联系起来的最新研究成果。
