Castanier Céline, Arnoult Damien
Inserm U1014 et Université Paris-Sud, Hôpital Paul Brousse, bâtiment Lavoisier, 14, avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France.
Med Sci (Paris). 2010 Oct;26(10):830-5. doi: 10.1051/medsci/20102610830.
Mitochondria exist as dynamic networks that often change shape and subcellular distribution. The morphology of mitochondria within a cell is controlled by precisely regulated rates of organelle fusion and fission. Several reports have described dramatic alterations in mitochondrial morphology during the early stages of apoptosis: a fragmentation of the network and the cristae remodeling. However, whether this mitochondrial fragmentation is a required step for apoptosis is highly debated. In this review the recent progress in understanding the mechanisms governing mitochondrial morphology during apoptosis and the latest advances connecting the regulation of mitochondrial morphology with apoptosis are discussed.
线粒体以动态网络的形式存在，其形态和亚细胞分布经常发生变化。细胞内线粒体的形态由细胞器融合和裂变的精确调控速率控制。有几份报告描述了凋亡早期线粒体形态的显著改变：网络碎片化和嵴重塑。然而，这种线粒体碎片化是否是凋亡的必要步骤仍存在激烈争论。在这篇综述中，我们讨论了在理解凋亡过程中线粒体形态调控机制方面的最新进展，以及将线粒体形态调控与凋亡联系起来的最新研究成果。
