宫颈上皮内瘤变（CIN）冷凝治疗的疗效
Efficacy of cervical intrarepithelial neoplasia (CIN) treatment by cold coagulation.
作者信息
Zawislak A, Price J H, McClelland H R, Storey R G N, Caughley L
机构信息
Department of Gynaecology, Belfast City Hospital, Lisburn Road, Belfast BT9 6AB.
出版信息
Ulster Med J. 2003 May;72(1):10-5.
Our objective was to evaluate the efficacy of cold coagulation in the treatment of cervical intraepithelial neoplasia. The study design consisted of a retrospective review of case records of all women treated with cold coagulation from the colposcopy clinics inception in 1980 to 1994. A total of 725 women received treatment with cold coagulation. All grades of CIN were treated. 632 (87.1%) had long term negative follow up. 93 (12.6%) of patients had abnormal cytological follow up, but only 45 (6.2%) required re-treatment. Within the first year after treatment 52 (7.1%) patients presented with persistent cytological abnormalities, 32 (4.4%) required repeated treatment for persistent dyskaryosis. 41 (5.6%) of patients had recurrent cytological abnormalities, 13 (1.8%) required repeated treatment. Recurrence developed between two and 12 years from initial treatment. One case of cervical carcinoma following treatment with cold coagulation was recorded. Our data suggest that cold coagulation appears to be safe, efficient treatment for cervical intraepithelial neoplasia.
我们的目的是评估冷凝治疗宫颈上皮内瘤变的疗效。本研究设计为回顾性分析1980年至1994年阴道镜诊所成立以来所有接受冷凝治疗的女性病例记录。共有725名女性接受了冷凝治疗。所有级别宫颈上皮内瘤变（CIN）均接受了治疗。632例（87.1%）获得长期阴性随访结果。93例（12.6%）患者细胞学随访结果异常，但仅45例（6.2%）需要再次治疗。治疗后第一年内，52例（7.1%）患者出现持续性细胞学异常，32例（4.4%）因持续性核异质需要重复治疗。41例（5.6%）患者出现复发性细胞学异常，13例（1.8%）需要重复治疗。复发发生在初始治疗后的2至12年。记录到1例冷凝治疗后发生宫颈癌的病例。我们的数据表明，冷凝治疗似乎是治疗宫颈上皮内瘤变安全、有效的方法。
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