Linington Roger G, Williams David E, Tahir Akbar, van Soest Rob, Andersen Raymond J
Department of Chemistry, University of British Columbia, Vancouver, B.C., Canada V6T 1Z1.
Org Lett. 2003 Jul 24;5(15):2735-8. doi: 10.1021/ol034950b.
[structure: see text] Latonduines A (6) and B (7), two new alkaloids with unprecedented heterocyclic skeletons, have been isolated from the Indonesian marine sponge Stylissa carteri. The structures of the latonduines were elucidated by analysis of spectroscopic data and confirmed by the total synthesis of latonduine A (6). It is proposed that ornithine is the biogenetic precursor to the aminopyrimidine fragment of the latonduines.
[结构：见正文] 从印度尼西亚海洋海绵卡特里柱星螅（Stylissa carteri）中分离出了拉通杜因A（6）和B（7）这两种具有前所未有的杂环骨架的新生物碱。通过光谱数据分析阐明了拉通杜因的结构，并通过拉通杜因A（6）的全合成得到了证实。有人提出鸟氨酸是拉通杜因氨基嘧啶片段的生物合成前体。
