石松锯叶石松中一种含肟的新型石松生物碱——石松锯叶胺-B的结构解析与合成

Structure elucidation and synthesis of lycoposerramine-B, a novel oxime-containing Lycopodium alkaloid from Lycopodium serratum Thunb.

作者信息

Katakawa Kazuaki, Kitajima Mariko, Aimi Norio, Seki Hiroko, Yamaguchi Kentaro, Furihata Kazuo, Harayama Takashi, Takayama Hiromitsu

机构信息

Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.

出版信息

J Org Chem. 2005 Jan 21;70(2):658-63. doi: 10.1021/jo0483825.

DOI:10.1021/jo0483825

PMID:15651814

Abstract

A new alkaloid, lycoposerramine-B (1), containing an oxime function, was isolated from the club moss Lycopodium serratum Thunb. The structure of 1 was elucidated by spectroscopic analysis, including J-resolved HMBC spectroscopy, and confirmed by its synthesis from the known alkaloid, serratinine (3).

摘要

从石松科植物锯齿石松（Lycopodium serratum Thunb.）中分离出一种新的含有肟官能团的生物碱——石松锯叶碱-B（1）。通过光谱分析，包括J-分辨HMBC光谱对1的结构进行了阐明，并通过由已知生物碱锯叶石松宁（3）合成1进行了确证。