胺催化源自费歇尔卡宾配合物的醛与烯酮的偶联反应：β-内酯和烯醇醚的形成
Amine-catalyzed coupling of aldehydes and ketenes derived from Fischer carbene complexes: formation of beta-lactones and enol ethers.
作者信息
Merlic Craig A, Doroh Brandon C
机构信息
Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles Young Drive, Los Angeles, California 90095-1569, USA.
出版信息
J Org Chem. 2003 Jul 25;68(15):6056-9. doi: 10.1021/jo034476n.
PMID:12868950
Abstract
Aldehydes react with ketenes generated from photolysis of Fischer chromium carbene complexes to generate either beta-lactones or enol ethers resulting from decarboxylation of beta-lactones. The reaction is catalyzed by tertiary amines and can occur with diastereoselectivity greater than 20:1 with DMAP as the catalyst.
摘要
醛与费歇尔铬卡宾配合物光解产生的烯酮反应，生成β-内酯或由β-内酯脱羧产生的烯醇醚。该反应由叔胺催化，以4-二甲氨基吡啶为催化剂时，可发生非对映选择性大于20:1的反应。
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