Huang Haw-Ming, Chiu Ching-Lai, Yeh Ching-Ying, Lin Che-Tong, Lin Li-Hsiang, Lee Sheng-Yang
School of Medical Technology, Taipei Medical University, Taipei, Taiwan.
Clin Oral Implants Res. 2003 Aug;14(4):437-43. doi: 10.1034/j.1600-0501.2003.00818.x.
In this study, in vitro and in vivo models were adopted for assessing the application of resonance frequency analysis (RFA) in the early detection of implant stability. In the in vitro tests, RF values of implants placed in bone block with predrilled cavities of 3.75 and 5.0 mm were measured and compared. Stone was used to fill the inter-space between implants and the bone blocks. Our results showed that poor initial stability conditions contributed to a lower initial RF (IRF) value (5.41+/-0.32 kHz) and a longer simulated healing period (41 min) than that of well-fitted conditions (9.63+/-0.34 kHz for IRF, 14 min for the simulated healing period, P<0.05). To validate such in vitro tests, animal models were also performed. Implants were placed in the left tibias of six rabbits using a general surgery procedure. The modal testing method was used to test the RF values of the implants. The RF values of the implants increased significantly (P<0.05) during the healing period and reached a plateau when the implant-bone interface was united. The variations of RF values of the testing implants showed a similar trend to the results of in vitro tests, i.e., implants with higher initial RF values had shorter simulated healing times. Based on these findings, we concluded that RFA is a reliable and accurate method for early assessment of the osseointegration process.
在本研究中，采用体外和体内模型来评估共振频率分析（RFA）在种植体稳定性早期检测中的应用。在体外试验中，测量并比较了植入到预钻有3.75毫米和5.0毫米孔洞的骨块中的种植体的射频值。用石头填充种植体与骨块之间的间隙。我们的结果表明，与适配良好的情况相比，初始稳定性较差的情况导致较低的初始射频（IRF）值（5.41±0.32千赫兹）和更长的模拟愈合期（41分钟），而适配良好的情况的IRF为9.63±0.34千赫兹，模拟愈合期为14分钟，P<0.05。为了验证此类体外试验，还进行了动物模型实验。采用普通外科手术方法将种植体植入六只兔子的左胫骨中。使用模态测试方法测试种植体的射频值。在愈合期，种植体的射频值显著增加（P<0.05），当种植体 - 骨界面结合时达到稳定状态。测试种植体的射频值变化与体外试验结果呈现相似趋势，即初始射频值较高的种植体模拟愈合时间较短。基于这些发现，我们得出结论，RFA是早期评估骨结合过程的一种可靠且准确的方法。
