Wallis Jonathan P, Lubenko Anatole, Wells Angus W, Chapman Catherine E
Department of Hematology, Freeman Hospital, and the National Blood Service, Newcastle upon Tyne, UK.
Transfusion. 2003 Aug;43(8):1053-9. doi: 10.1046/j.1537-2995.2003.00466.x.
TRALI is a serious adverse effect of blood transfusion. There is evidence that the condition is underrecognized and underreported.
This study was an observational study carried out in a single hospital.
Eleven cases of TRALI were recognized over 12 years. In 10 cases the implicated donor unit was FFP and in 1 case uncertain. All implicated donors were parous women. In 4 cases the presumed causative antibodies were to an HLA class II antigen only. Specific anti-neutrophil antibodies, possibly causative, were detected in 1 case only. Ten of the 11 cases required mechanical ventilatory support. Five persons died as a result of the TRALI. The observed incidence of TRALI caused by FFP is 1 in 7900 units transfused.
TRALI is the most common serious adverse effect of blood transfusion in our hospital. Antibodies to HLA class II antigens should be looked for routinely when investigating a possible case of TRALI.
输血相关急性肺损伤（TRALI）是输血的一种严重不良反应。有证据表明该病症未得到充分认识和报告。
本研究是在一家医院开展的观察性研究。
在12年期间共识别出11例TRALI。其中10例涉及的供体单位为新鲜冰冻血浆（FFP），1例情况不明。所有涉及的供体均为经产妇。4例中推测的致病抗体仅针对人类白细胞抗原（HLA）Ⅱ类抗原。仅在1例中检测到可能致病的特异性抗中性粒细胞抗体。11例中有10例需要机械通气支持。5人因TRALI死亡。FFP所致TRALI的观察发病率为每输注7900单位出现1例。
TRALI是我院输血最常见的严重不良反应。在调查可能的TRALI病例时，应常规检测HLAⅡ类抗原抗体。
