Miyazaki K, Higaki S, Maruyama T, Takahashi S, Morohashi M, Ito K
Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
J Dermatol. 1993 Apr;20(4):242-6. doi: 10.1111/j.1346-8138.1993.tb03869.x.
The clinical and histopathological findings in a 25-year-old Japanese male patient who suffered from chronic graft-versus-host-disease (GVHD) with follicular involvement are described. The patient had been diagnosed as aplastic anemia and underwent an allogeneic bone marrow transplant (BMT). In the eighth month thereafter, pruritic follicular red papules developed over his trunk and extremities. A biopsy specimen revealed histological exocytosis of lymphocytes into the hair follicles and basal-cell vacuolization of the follicular epithelium. Analysis of T-lymphocyte subpopulations in the dermis revealed a predominance of CD4 positive cells. To our knowledge, several cases of acute follicular GVHD have been reported; however, the occurrence of chronic GVHD with follicular involvement (chronic follicular GVHD) has not been clearly documented.
本文描述了一名25岁日本男性患者的临床和组织病理学表现，该患者患有慢性移植物抗宿主病（GVHD）且累及毛囊。患者曾被诊断为再生障碍性贫血，并接受了异基因骨髓移植（BMT）。此后第八个月，其躯干和四肢出现瘙痒性毛囊红色丘疹。活检标本显示淋巴细胞向毛囊的组织学外渗以及毛囊上皮的基底细胞空泡化。对真皮中T淋巴细胞亚群的分析显示CD4阳性细胞占优势。据我们所知，已有数例急性毛囊GVHD的报道；然而，慢性GVHD累及毛囊（慢性毛囊GVHD）的发生尚未得到明确记载。
