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[主动脉弓手术中逆行与选择性脑灌注时脑血管氧饱和度变化的比较]

[A comparison of changes of cerebrovascular oxygen saturation in retrograde and selective cerebral perfusion during aortic arch surgery].

作者信息

Higami T, Kozawa S, Asada T, Mukohara N, Obo H, Gan K, Iwahashi K, Ogawa K

机构信息

Division of Cardiovascular Surgery, Hyogo Brain and Heart Center at Himeji, Japan.

出版信息

Nihon Kyobu Geka Gakkai Zasshi. 1995 Dec;43(12):1919-23.

PMID:8551072
Abstract

To evaluate the effect of retrograde cerebral perfusion (RCP) and selective cerebral perfusion (SCP) on brain protection, changes of cerebrovascular oxygen saturation (rSO2) were studied in 14 patients with aortic arch reconstruction during the procedure. The rSO2 was monitored with spectroscopy instrument (Invos 3100, Somanetics). The mean value of rSO2 measured just before cardiopulmonary bypass was 65.9 +/- 6.2% in 7 patients with RCP, and was 64.9 +/- 4.7% in 7 patients with SCP. The value of rSO2 during core cooling of cardiopulmonary bypass was increased step by step. Although RCP time with a mean of 38.9 +/- 9.7 min was statistically shorter than SCP time (80.7 +/- 45.1 min), the mean value of rSO2 during cerebral protection in RCP group was decreased from 80.3 +/- 8.1% to 63.4 +/- 10.2%, lowest 46% with a ratio of 21.1%. In contrast, the mean value of rSO2 in SCP group was well maintained from 79.9 +/- 6.5 to 75.6 +/- 6.8%, lowest 63% with a ratio of 5.4%. Although no neurological deficits were recognized after operation in both groups, rSO2 in SCP group was sustained above the control value (65% just before cardiopulmonary bypass) but rSO2 in RCP group was decreased below the control value after 35 min. So we conclude that with regard to brain protection assessed from rSO2 measured by Invos 3100 cerebral oximeter, there is no time limitation of SCP during the procedure but RCP had a limit of the duration.

摘要

为评估逆行脑灌注(RCP)和选择性脑灌注(SCP)对脑保护的效果,在手术过程中对14例行主动脉弓重建术的患者的脑血管血氧饱和度(rSO2)变化进行了研究。使用光谱仪(Invos 3100,Somanetics)监测rSO2。7例行RCP的患者在体外循环前测得的rSO2平均值为65.9±6.2%,7例行SCP的患者为64.9±4.7%。体外循环核心降温期间rSO2值逐步升高。虽然RCP平均时间为38.9±9.7分钟,在统计学上短于SCP时间(80.7±45.1分钟),但RCP组脑保护期间rSO2平均值从80.3±8.1%降至63.4±10.2%,最低为46%,比例为21.1%。相比之下,SCP组rSO2平均值从79.9±6.5%维持在75.6±6.8%,最低为63%,比例为5.4%。虽然两组术后均未发现神经功能缺损,但SCP组rSO2维持在对照值(体外循环前为65%)以上,而RCP组rSO2在35分钟后降至对照值以下。因此我们得出结论,就通过Invos 3100脑血氧饱和度仪测量的rSO2评估脑保护而言,手术过程中SCP没有时间限制,但RCP存在持续时间限制。

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