Stephan Klaas E, Marshall John C, Friston Karl J, Rowe James B, Ritzl Afra, Zilles Karl, Fink Gereon R
Institute of Medicine (IME), Research Centre Jülich, 52425 Jülich, Germany.
Science. 2003 Jul 18;301(5631):384-6. doi: 10.1126/science.1086025.
The principles underlying human hemispheric specialization are poorly understood. We used functional magnetic resonance imaging of letter and visuospatial decision tasks with identical word stimuli to address two unresolved problems. First, hemispheric specialization depended on the nature of the task rather than on the nature of the stimulus. Second, analysis of frontal candidate regions for cognitive control showed increased coupling between left anterior cingulate cortex (ACC) and left inferior frontal gyrus during letter decisions, whereas right ACC showed enhanced coupling with right parietal areas during visuospatial decisions. Cognitive control is thus localized in the same hemisphere as task execution.
人类半球特化的潜在原理尚不清楚。我们使用功能磁共振成像技术，对字母和视觉空间决策任务进行相同单词刺激，以解决两个未解决的问题。首先，半球特化取决于任务的性质，而不是刺激的性质。其次，对认知控制的额叶候选区域的分析表明，在字母决策过程中，左前扣带回皮质（ACC）和左下额叶回之间的耦合增加，而在视觉空间决策过程中，右ACC与右顶叶区域的耦合增强。因此，认知控制与任务执行位于同一半球。
