Xing Y, Kuang A
Department of Nuclear Medicine, West China Hospital, sichuan University, Chengdu, Sichuan Province, China.
Nucl Med Commun. 2003 Aug;24(8):853-6. doi: 10.1097/01.mnm.0000084582.29433.96.
Thyroperoxidase (TPO) is a glycosylated protein bound to the apical plasma membrane of thyrocytes. It is the key enzyme in the synthesis of thyroid hormones. Its gene structure and transcriptional regulation have been studied in detail. This article reviews the structure, function and transcriptional regulation of the TPO gene, and the relationship between TPO, thyroid diseases and radioactive iodide therapy.
甲状腺过氧化物酶（TPO）是一种与甲状腺细胞顶端质膜结合的糖蛋白。它是甲状腺激素合成中的关键酶。其基因结构和转录调控已得到详细研究。本文综述了TPO基因的结构、功能和转录调控，以及TPO、甲状腺疾病和放射性碘治疗之间的关系。
