Schmiedehausen K, Kat S, Albert N, Platsch G, Wildt L, Kuwert T
Clinic of Nuclear Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Germany.
Nucl Med Commun. 2003 Aug;24(8):865-70. doi: 10.1097/01.mnm.0000084577.51410.c4.
Transport of 99mTc labelled albumin macroaggregates (MAA) can be used as a substitute for assessing transport of spermatozoa within the female genital tract. As yet, the velocity of tubar MAA transport has not been systematically studied in a large group. Dynamic hysterosalpingoscintigraphy (HSS) was performed after intrauterine instillation of 10-20 MBq 99mTc-MAA in 88 pre-ovulatory women suffering from infertility. They had to have anatomical patency of both tubes and at least one enlarged follicle. The direction and the latency of transport were evaluated. Forty-four per cent of patients exhibited MAA transport only to the dominant follicle, 31% to both ovaries and 16% to the contralateral ovary. In 9% no transport was visible. Fifty per cent of all patients studied exhibited MAA transport to the dominant follicle within 30 s, 75% within 20 min. Transport velocity in women having bilateral or ipsilateral transport did not differ significantly. There was no significant correlation between the size of the follicle and transport velocity. We conclude that in the majority of cases MAA transport occurs within 30 s after instillation. The variation in transport time between 30 s and 20 min suggests that dynamic scintigraphy is, in principle, better suited to a refined analysis of tubar function than static HSS.
99mTc标记的白蛋白大聚合体（MAA）的转运可用于替代评估精子在女性生殖道内的转运情况。迄今为止，尚未在一大组人群中对输卵管MAA的转运速度进行系统研究。对88名排卵前不孕女性在子宫内注入10 - 20 MBq的99mTc - MAA后进行动态子宫输卵管闪烁造影（HSS）。这些女性双侧输卵管必须解剖通畅且至少有一个增大的卵泡。评估了转运的方向和潜伏期。44%的患者显示MAA仅转运至优势卵泡，31%转运至双侧卵巢，16%转运至对侧卵巢。9%未见转运。所有研究患者中有50%在30秒内MAA转运至优势卵泡，75%在20分钟内。双侧或同侧转运的女性之间的转运速度无显著差异。卵泡大小与转运速度之间无显著相关性。我们得出结论，在大多数情况下，注入后30秒内会发生MAA转运。30秒至20分钟之间转运时间的变化表明，原则上动态闪烁造影比静态HSS更适合对输卵管功能进行精细分析。
