高轮瓦烯，由链霉菌属K99-5278菌株产生的新型抗真菌抗生素。I. 分类学、发酵、分离及生物学特性

Takanawaenes, novel antifungal antibiotics produced by Streptomyces sp. K99-5278. I. Taxonomy, fermentation, isolation and biological properties.

作者信息

Kim Yong-Pil, Tomoda Hiroshi, Iizima Kousuke, Fukuda Takashi, Matsumoto Atsuko, Takahashi Yoko, Omura Satoshi

机构信息

Kitasato Institute for Life Sciences, Kitasato University and The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.

出版信息

J Antibiot (Tokyo). 2003 May;56(5):448-53. doi: 10.7164/antibiotics.56.448.

DOI:10.7164/antibiotics.56.448

PMID:12870809

Abstract

Three new pentaene macrolides having a 28-membered ring, designated takanawaenes A, B and C, were isolated from the fermentation broth of Streptomyces sp. K99-5278 by solvent extraction, silica-gel column chromatography and HPLC. Takanawaenes showed antifungal activity against Aspergillus niger, Mucor racemosus, Candida albicans and Saccharomyces cerevisiae.

摘要

从链霉菌属菌株K99 - 5278的发酵液中，通过溶剂萃取、硅胶柱色谱法和高效液相色谱法分离出三种新的具有28元环的戊二烯大环内酯类化合物，命名为高轮烯A、B和C。高轮烯对黑曲霉、总状毛霉、白色念珠菌和酿酒酵母显示出抗真菌活性。