雷帕霉素（AY - 22,989），一种新型抗真菌抗生素。II. 发酵、分离与特性鉴定
Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.
作者信息
Sehgal S N, Baker H, Vézina C
出版信息
J Antibiot (Tokyo). 1975 Oct;28(10):727-32. doi: 10.7164/antibiotics.28.727.
Rapamycin is a new antifungal antibiotic produced by Streptomyces hygroscopicus NRRL 5491. It was isolated from the mycelium by solvent extraction, purified by silica gel column chromatography and crystallized as a colorless solid which melts at 183 approximately to 185 degrees C and has the empirical formula C56H89NO14. From its characteristic ultraviolet absorption spectrum rapamycin can be classified as a triene. It is highly active against various Candida species, especially Candida albicans. Its activity is compared with that of amphotericin B, candicidin and nystatin.
雷帕霉素是一种由吸水链霉菌NRRL 5491产生的新型抗真菌抗生素。它通过溶剂萃取从菌丝体中分离出来，经硅胶柱色谱法纯化，并结晶为无色固体，熔点约为183至185摄氏度，实验式为C56H89NO14。根据其特征紫外吸收光谱，雷帕霉素可归类为三烯类。它对各种念珠菌属具有高度活性，尤其是白色念珠菌。将其活性与两性霉素B、杀假丝菌素和制霉菌素的活性进行了比较。
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