Bazil Carl W
Columbia Comprehensive Epilepsy Center, New York, New York 10032, USA.
CNS Drugs. 2003;17(10):719-28. doi: 10.2165/00023210-200317100-00003.
Good-quality sleep is an important and frequently overlooked component of general health, but it is particularly essential to patients with epilepsy. Their sleep can be affected by seizures, concurrent sleep disorders and seizure treatment. Worsening sleep can result not only in poor daytime functioning but also potentially in worsening epilepsy. The effects of antiepileptic drugs (AEDs) on sleep are of particular concern. Some agents have detrimental effects on sleep, particularly benzodiazepines and barbiturates but also phenytoin and, possibly, carbamazepine. Others, especially gabapentin, seem to actually improve sleep quality. Much research in this area is confounded by the effects of seizures and concurrent conditions on sleep, making it difficult to isolate the direct effects of AEDs on sleep. But because AEDs have independent effects on sleep quality, the choice of an appropriate agent not only determines whether seizures are completely controlled but also whether the patient performs optimally on a daily basis.
优质睡眠是整体健康的一个重要但常被忽视的组成部分，而对于癫痫患者来说尤为关键。他们的睡眠会受到癫痫发作、并发睡眠障碍及癫痫治疗的影响。睡眠质量变差不仅会导致白天功能不佳，还可能使癫痫病情恶化。抗癫痫药物（AEDs）对睡眠的影响尤其值得关注。一些药物对睡眠有不利影响，特别是苯二氮䓬类和巴比妥类药物，还有苯妥英，可能还有卡马西平。其他药物，尤其是加巴喷丁，似乎实际上能改善睡眠质量。该领域的许多研究因癫痫发作及并发疾病对睡眠的影响而变得复杂，难以分离出AEDs对睡眠的直接影响。但由于AEDs对睡眠质量有独立影响，选择合适的药物不仅决定癫痫发作是否能得到完全控制，还决定患者日常表现是否最佳。
