• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy.辅助性吡仑帕奈对癫痫患者睡眠质量和日间嗜睡的影响。
Epilepsy Behav Case Rep. 2016 Oct 21;7:13-15. doi: 10.1016/j.ebcr.2016.10.002. eCollection 2017.
2
Sleep quality and daytime sleepiness in patients treated with adjunctive perampanel for focal seizures.接受吡仑帕奈辅助治疗局灶性癫痫患者的睡眠质量和日间嗜睡情况。
Epilepsy Behav. 2016 Oct;63:57-62. doi: 10.1016/j.yebeh.2016.08.004. Epub 2016 Aug 24.
3
Sleep-wake cycle and daytime sleepiness in patients with epilepsy after initiating perampanel as adjunctive therapy.作为辅助治疗开始使用吡仑帕奈后癫痫患者的睡眠-觉醒周期和日间嗜睡情况。
Neurol Sci. 2023 Apr;44(4):1361-1368. doi: 10.1007/s10072-022-06536-4. Epub 2022 Dec 8.
4
Perampanel effect on sleep architecture in patients with epilepsy.吡仑帕奈对癫痫患者睡眠结构的影响。
Seizure. 2020 Feb 10;76:137-142. doi: 10.1016/j.seizure.2020.01.021.
5
Sleep quality and daytime sleepiness in epilepsy: Systematic review and meta-analysis of 25 studies including 8,196 individuals.癫痫患者的睡眠质量和日间嗜睡：包含 8196 人的 25 项研究的系统评价和荟萃分析。
Sleep Med Rev. 2021 Jun;57:101466. doi: 10.1016/j.smrv.2021.101466. Epub 2021 Mar 13.
6
Wake up to sleep: The effects of lacosamide on daytime sleepiness in adults with epilepsy.从睡眠中醒来：拉科酰胺对癫痫成年患者日间嗜睡的影响。
Epilepsy Behav. 2017 Oct;75:176-182. doi: 10.1016/j.yebeh.2017.08.002. Epub 2017 Sep 1.
7
High prevalence of pathological alertness and wakefulness on maintenance of wakefulness test in adults with focal-onset epilepsy.在局灶性癫痫发作的成年人中，维持清醒试验中病理性警觉和清醒的发生率较高。
Epilepsy Behav. 2021 Dec;125:108400. doi: 10.1016/j.yebeh.2021.108400. Epub 2021 Nov 17.
8
Comparing sleep profiles between patients with juvenile myoclonic epilepsy and symptomatic partial epilepsy: Sleep questionnaire-based study.青少年肌阵挛癫痫患者与症状性局灶性癫痫患者睡眠特征的比较：基于睡眠问卷的研究。
Epilepsy Behav. 2017 Jan;66:34-38. doi: 10.1016/j.yebeh.2016.10.009. Epub 2016 Dec 22.
9
Sleep and daytime sleepiness in retinitis pigmentosa patients.视网膜色素变性患者的睡眠与日间嗜睡情况
J Sleep Res. 2001 Dec;10(4):329-35. doi: 10.1046/j.1365-2869.2001.00271.x.
10
Effects of zonisamide as add-on therapy on sleep-wake cycle in focal epilepsy: a polysomnographic study.左乙拉西坦添加治疗对局灶性癫痫患者睡眠-觉醒周期的影响：一项多导睡眠图研究。
Epilepsy Behav. 2013 Feb;26(2):170-4. doi: 10.1016/j.yebeh.2012.11.049. Epub 2013 Jan 9.

引用本文的文献

1
Factors Affecting Sleep and Wakefulness in People with Epilepsy: A Narrative Review.癫痫患者睡眠与觉醒的影响因素：叙述性综述
Medicina (Kaunas). 2025 May 28;61(6):1000. doi: 10.3390/medicina61061000.
2
Circadian attributes of neurological and psychiatric disorders as basis for their medication chronotherapy.神经和精神疾病的昼夜节律属性作为其药物时辰疗法的基础。
Adv Drug Deliv Rev. 2025 Aug;223:115576. doi: 10.1016/j.addr.2025.115576. Epub 2025 Apr 3.
3
The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy.吡仑帕奈的广谱活性：AMPA拮抗作用在癫痫之外的研究现状与未来展望
Front Neurol. 2023 Jul 6;14:1182304. doi: 10.3389/fneur.2023.1182304. eCollection 2023.
4
Effects of antiepileptic drugs on sleep architecture parameters in adults.抗癫痫药物对成人睡眠结构参数的影响。
Sleep Sci. 2022 Apr-Jun;15(2):224-244. doi: 10.5935/1984-0063.20220045.

本文引用的文献

1
Long-term safety of perampanel and seizure outcomes in refractory partial-onset seizures and secondarily generalized seizures: results from phase III extension study 307.在耐药性部分发作性癫痫和继发全面性发作中，吡仑帕奈的长期安全性和癫痫发作结局：来自 III 期扩展研究 307 的结果。
Epilepsia. 2014 Jul;55(7):1058-68. doi: 10.1111/epi.12643. Epub 2014 May 27.
2
A multicenter survey of clinical experiences with perampanel in real life in Germany and Austria.一项关于吡仑帕奈在德国和奥地利真实世界临床应用经验的多中心调查。
Epilepsy Res. 2014 Jul;108(5):986-8. doi: 10.1016/j.eplepsyres.2014.03.015. Epub 2014 Mar 27.
3
Perampanel for adjunctive treatment of partial-onset seizures: a pooled dose-response analysis of phase III studies.吡仑帕奈辅助治疗部分发作性癫痫的疗效：III 期研究的汇总剂量反应分析。
Epilepsia. 2014 Mar;55(3):423-31. doi: 10.1111/epi.12527. Epub 2014 Mar 7.
4
Perampanel: a selective AMPA antagonist for treating seizures.吡仑帕奈：一种用于治疗癫痫的选择性 AMPA 拮抗剂。
Epilepsy Curr. 2013 Nov;13(6):269-72. doi: 10.5698/1535-7597-13.6.269.
5
Effects of epilepsy treatments on sleep architecture and daytime sleepiness: an evidence-based review of objective sleep metrics.癫痫治疗对睡眠结构和日间嗜睡的影响：客观睡眠指标的循证综述。
Epilepsia. 2014 Jan;55(1):26-37. doi: 10.1111/epi.12478. Epub 2013 Dec 2.
6
Efficacy and safety of adjunctive perampanel for the treatment of refractory partial seizures: a pooled analysis of three phase III studies.附加性培米贝鲁治疗难治性部分性癫痫发作的疗效和安全性：三项 III 期研究的汇总分析。
Epilepsia. 2013 Aug;54(8):1481-9. doi: 10.1111/epi.12212. Epub 2013 May 10.
7
Clinical review: Sleep measurement in critical care patients: research and clinical implications.临床综述：重症监护患者的睡眠测量：研究与临床意义
Crit Care. 2007;11(4):226. doi: 10.1186/cc5966.
8
Sleep and epilepsy: what we know, don't know, and need to know.睡眠与癫痫：我们所知道的、不知道的以及需要知道的。
J Clin Neurophysiol. 2006 Feb;23(1):4-20. doi: 10.1097/01.wnp.0000206877.90232.cb.
9
Effects of antiepileptic drugs on sleep architecture: a pilot study.抗癫痫药物对睡眠结构的影响：一项初步研究。
Sleep Med. 2003 Jan;4(1):51-5. doi: 10.1016/s1389-9457(02)00217-4.
10
Effects of antiepileptic drugs on sleep structure : are all drugs equal?抗癫痫药物对睡眠结构的影响：所有药物都一样吗？
CNS Drugs. 2003;17(10):719-28. doi: 10.2165/00023210-200317100-00003.

辅助性吡仑帕奈对癫痫患者睡眠质量和日间嗜睡的影响。

Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy.

作者信息

González-Cuevas Montserrat, Romero Odile, Toledo Manuel, Quintana Manuel, Cambrodí Roser, Santamarina Estevo, Jurado Maria José, Ferrer Alex, Salas-Puig Xavier

机构信息

Epilepsy Unit, Neurology Department, Hospital Vall Hebron, Barcelona, Spain.

Sleep Unit, Neurophysiology Department, Hospital Vall Hebron, Barcelona, Spain.

出版信息

Epilepsy Behav Case Rep. 2016 Oct 21;7:13-15. doi: 10.1016/j.ebcr.2016.10.002. eCollection 2017.

DOI:10.1016/j.ebcr.2016.10.002
PMID:28066710
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5200874/
Abstract

This prospective uncontrolled study evaluated the effect of low-dose adjunctive perampanel therapy (4 mg/day for 3 months) on the sleep-wake cycle and daytime somnolence in adult patients (n = 10) with focal seizures. A > 50% reduction in the number of seizures was reported in 80% of the study patients; treatment had no significant effect on any sleep parameters as evident by the Maintenance of Wakefulness Test, Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale scores. Two patients reported dizziness with treatment. In conclusion, low-dose perampanel may improve seizure control without affecting the sleep characteristics or daytime somnolence in patients with epilepsy.

摘要

这项前瞻性非对照研究评估了低剂量辅助吡仑帕奈治疗（4毫克/天，持续3个月）对10例局灶性癫痫成年患者睡眠-觉醒周期和日间嗜睡的影响。80%的研究患者报告癫痫发作次数减少超过50%；通过清醒维持测试、匹兹堡睡眠质量指数和爱泼华嗜睡量表评分可知，治疗对任何睡眠参数均无显著影响。两名患者报告治疗期间出现头晕。总之，低剂量吡仑帕奈可能改善癫痫控制，而不影响癫痫患者的睡眠特征或日间嗜睡情况。