辅助性吡仑帕奈对癫痫患者睡眠质量和日间嗜睡的影响。
Effect of adjunctive perampanel on the quality of sleep and daytime somnolence in patients with epilepsy.
作者信息
González-Cuevas Montserrat, Romero Odile, Toledo Manuel, Quintana Manuel, Cambrodí Roser, Santamarina Estevo, Jurado Maria José, Ferrer Alex, Salas-Puig Xavier
机构信息
Epilepsy Unit, Neurology Department, Hospital Vall Hebron, Barcelona, Spain.
Sleep Unit, Neurophysiology Department, Hospital Vall Hebron, Barcelona, Spain.
出版信息
Epilepsy Behav Case Rep. 2016 Oct 21;7:13-15. doi: 10.1016/j.ebcr.2016.10.002. eCollection 2017.
Abstract
This prospective uncontrolled study evaluated the effect of low-dose adjunctive perampanel therapy (4 mg/day for 3 months) on the sleep-wake cycle and daytime somnolence in adult patients (n = 10) with focal seizures. A > 50% reduction in the number of seizures was reported in 80% of the study patients; treatment had no significant effect on any sleep parameters as evident by the Maintenance of Wakefulness Test, Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale scores. Two patients reported dizziness with treatment. In conclusion, low-dose perampanel may improve seizure control without affecting the sleep characteristics or daytime somnolence in patients with epilepsy.
摘要
这项前瞻性非对照研究评估了低剂量辅助吡仑帕奈治疗（4毫克/天，持续3个月）对10例局灶性癫痫成年患者睡眠-觉醒周期和日间嗜睡的影响。80%的研究患者报告癫痫发作次数减少超过50%；通过清醒维持测试、匹兹堡睡眠质量指数和爱泼华嗜睡量表评分可知，治疗对任何睡眠参数均无显著影响。两名患者报告治疗期间出现头晕。总之，低剂量吡仑帕奈可能改善癫痫控制，而不影响癫痫患者的睡眠特征或日间嗜睡情况。
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