Maag Jennifer, Prayson Richard A
Department of Anatomic Pathology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Arch Pathol Lab Med. 2003 Aug;127(8):1037-9. doi: 10.5858/2003-127-1037-ISTIAP.
There is a well-known risk of thrombosis in patients with inflammatory bowel disease. Documented cases of intracranial sinus thrombosis in this setting are rare. We present the case of a 30-year-old man with Crohn disease who spontaneously developed a superior sagittal sinus thrombosis and bifrontal infarcts that resulted in death. The patient was heterozygous for factor V Leiden mutation. The literature was searched to assess the frequency of cerebral venous infarcts in inflammatory bowel disease and the role that factor V Leiden plays in thrombosis in such patients.
炎症性肠病患者存在众所周知的血栓形成风险。在这种情况下，有记录的颅内窦血栓形成病例很少见。我们报告一例30岁克罗恩病男性患者，其自发发生上矢状窦血栓形成和双侧额叶梗死，最终导致死亡。该患者为凝血因子V莱顿突变杂合子。我们检索了文献，以评估炎症性肠病中脑静脉梗死的发生率以及凝血因子V莱顿在此类患者血栓形成中所起的作用。
