Eccles Ron, Loose Irene, Jawad Martez, Nyman Lars
Common Cold Centre, Cardiff University, UK.
Pain Med. 2003 Jun;4(2):118-24. doi: 10.1046/j.1526-4637.2003.03019.x.
Acetylsalicylic acid (ASA) has been widely used for over a century to treat pain and fever associated with acute upper respiratory tract infection (URTI), but there is a lack of clinical data to support the efficacy of ASA in this disease state. The objective of this study was to investigate the efficacy and safety of ASA for the treatment of sore throat pain associated with URTI.
A double-blinded, placebo-controlled, parallel group design. Two hundred seventy-two patients (mean age: 25 years) with sore throat pain associated with URTI were recruited at two centers. Pain scores were made during a 2-hour laboratory phase and continued for secondary objectives during a 4-hour home phase. Patients were treated with either two effervescent tablets of ASA 400 mg in water or matched placebo tablets. Patients took medication as required over a 3-day home phase.
ASA was found to be superior to placebo for: The primary efficacy parameter predefined in the protocol, reduction in sore throat pain intensity over 2 hours (P < 0.001), and for secondary efficacy parameters, reduction in sore throat pain intensity over 4 and 6 hours, relief of sore throat pain over 2, 4, and 6 hours, reduction in intensity of pain associated with headache, and reduction in muscle aches and pains over a 2-hour time period (P < 0.01). No safety problems were encountered.
Treatment with ASA was shown to provide relief from sore throat pain, headache, and muscle aches and pains associated with URTI.
乙酰水杨酸（ASA）已广泛应用一个多世纪，用于治疗与急性上呼吸道感染（URTI）相关的疼痛和发热，但缺乏临床数据支持ASA在这种疾病状态下的疗效。本研究的目的是调查ASA治疗与URTI相关的咽痛的疗效和安全性。
双盲、安慰剂对照、平行组设计。在两个中心招募了272例（平均年龄：25岁）与URTI相关的咽痛患者。在2小时的实验室阶段进行疼痛评分，并在4小时的家庭阶段继续进行次要目标评估。患者分别接受两片400mg ASA泡腾片溶于水中或匹配的安慰剂片治疗。患者在3天的家庭阶段根据需要服药。
发现ASA在以下方面优于安慰剂：方案中预先定义的主要疗效参数，即2小时内咽痛强度降低（P<0.001）；次要疗效参数包括4小时和6小时内咽痛强度降低、2小时、4小时和6小时内咽痛缓解、与头痛相关的疼痛强度降低以及2小时内肌肉疼痛减轻（P<0.01）。未遇到安全问题。
结果表明，ASA治疗可缓解与URTI相关的咽痛、头痛和肌肉疼痛。
