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1
Global burden of upper respiratory infections in 204 countries and territories, from 1990 to 2019.1990年至2019年期间204个国家和地区的上呼吸道感染全球负担
EClinicalMedicine. 2021 Jun 28;37:100986. doi: 10.1016/j.eclinm.2021.100986. eCollection 2021 Jul.
2
Increased Risk of Upper Respiratory Infection in Military Recruits Who Report Sleeping Less Than 6 h per night.每晚睡眠时间少于6小时的新兵上呼吸道感染风险增加。
Mil Med. 2018 Nov 1;183(11-12):e699-e704. doi: 10.1093/milmed/usy090.
3
Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti-inflammatory effects of eucalyptol.瞬时受体电位阳离子通道M亚家族成员8通道介导桉叶油醇的抗炎作用。
Br J Pharmacol. 2017 May;174(9):867-879. doi: 10.1111/bph.13760. Epub 2017 Mar 23.
4
Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells.呼吸道病毒感染会上调气道细胞上的TRPV1、TRPA1和ASIC3受体。
PLoS One. 2017 Feb 10;12(2):e0171681. doi: 10.1371/journal.pone.0171681. eCollection 2017.
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The Bidirectional Relationship between Sleep and Immunity against Infections.睡眠与抗感染免疫的双向关系。
J Immunol Res. 2015;2015:678164. doi: 10.1155/2015/678164. Epub 2015 Aug 31.
6
The natural history of community-acquired common colds symptoms assessed over 4-years.对社区获得性普通感冒症状的自然史进行了4年的评估。
Rhinology. 2015 Mar;53(1):81-8. doi: 10.4193/Rhino14.149.
7
Anti-inflammatory properties of the monoterpene 1.8-cineole: current evidence for co-medication in inflammatory airway diseases.单萜1,8-桉叶素的抗炎特性:炎症性气道疾病联合用药的当前证据。
Drug Res (Stuttg). 2014 Dec;64(12):638-46. doi: 10.1055/s-0034-1372609. Epub 2014 May 15.
8
Rhinovirus upregulates transient receptor potential channels in a human neuronal cell line: implications for respiratory virus-induced cough reflex sensitivity.鼻病毒上调人神经元细胞系中的瞬时受体电位通道:提示呼吸道病毒引起的咳嗽反射敏感性。
Thorax. 2014 Jan;69(1):46-54. doi: 10.1136/thoraxjnl-2013-203894. Epub 2013 Sep 3.
9
Impact of partial sleep deprivation on immune markers.部分睡眠剥夺对免疫标志物的影响。
Sleep Med. 2013 Oct;14(10):1031-4. doi: 10.1016/j.sleep.2013.07.001. Epub 2013 Aug 28.
10
The effect of inhaled menthol on upper airway resistance in humans: a randomized controlled crossover study.吸入薄荷醇对人体上呼吸道阻力的影响:一项随机对照交叉研究。
Can Respir J. 2013 Jan-Feb;20(1):e1-4. doi: 10.1155/2013/383019.

用于治疗普通感冒的芳香软膏:科学是怎么说的?

Aromatic ointments for the common cold: what does the science say?

作者信息

Smith Andrew, Matthews Oliver

机构信息

School of Psychology, Cardiff University, Cardiff, UK.

Procter and Gamble UK, Weybridge, Surrey, UK.

出版信息

Drugs Context. 2022 Aug 1;11. doi: 10.7573/dic.2022-5-6. eCollection 2022.

DOI:10.7573/dic.2022-5-6
PMID:35975030
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9354706/
Abstract

BACKGROUND

Upper respiratory tract infections occur with an annual incidence of 17.2 billion cases globally. The negative impact that symptoms have on sleep is thought to slow the recovery process. Plant-derived aromatics have been used since ancient times to treat respiratory illnesses. In this narrative review, we summarize the use of aromatics for the symptomatic relief of upper respiratory tract infections and how this affects sleep quality.

METHODS

Literature searches were conducted using a series of search terms and results were screened for relevance. Additional references were included according to the expert knowledge of the authors.

DISCUSSION

Multiple studies have observed that essential oil mixtures of aromatics enhance symptom relief for upper respiratory tract infections and their inhalation has been reported to have antitussive effects. Clinical trials assessing the efficacy of an ointment containing menthol, eucalyptus and camphor found patients to experience faster nasal cooling and decongestion times. Treatment with the same ointment also resulted in significant improvements in reported sleep quality. Aromatic treatment did not improve objective nasal airway measures in any of the studies.

CONCLUSION

Whilst not affecting objective measures of nasal airway resistance, the use of aromatics leads to improvements in a number of subjective sensations associated with the common cold. Such benefits result in better sleep, which likely aids recovery. Therefore, aromatics remain a well tolerated and effective option for the symptomatic relief of upper respiratory tract infections.

摘要

背景

全球上呼吸道感染的年发病例数达172亿例。症状对睡眠的负面影响被认为会减缓康复进程。植物源芳香剂自古以来就被用于治疗呼吸道疾病。在这篇叙述性综述中,我们总结了芳香剂用于缓解上呼吸道感染症状的情况以及其对睡眠质量的影响。

方法

使用一系列检索词进行文献检索,并筛选结果的相关性。根据作者的专业知识纳入其他参考文献。

讨论

多项研究观察到,芳香剂的精油混合物可增强上呼吸道感染症状的缓解,据报道吸入这些混合物具有镇咳作用。评估含有薄荷醇、桉叶油和樟脑的软膏疗效的临床试验发现,患者的鼻腔冷却和减轻充血时间更快。使用同一种软膏治疗也使报告的睡眠质量有显著改善。在任何研究中,芳香疗法均未改善客观的鼻气道指标。

结论

虽然芳香剂不影响鼻气道阻力的客观指标,但使用芳香剂可改善与普通感冒相关的多种主观感受。这些益处可带来更好的睡眠,这可能有助于康复。因此,芳香剂仍然是一种耐受性良好且有效的缓解上呼吸道感染症状的选择。