Devoto Alessandra, Muskett Paul R, Shirasu Ken
The Sainsbury Laboratory, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK.
Curr Opin Plant Biol. 2003 Aug;6(4):307-11. doi: 10.1016/s1369-5266(03)00060-8.
Ubiquitination is emerging as a common regulatory mechanism that controls a range of cellular processes in plants. Recent exciting discoveries from several laboratories suggest that ubiquitination may also play an important role in plant disease resistance. Several putative ubiquitin ligases have been identified as defence regulators. In addition, a combination of genetic screens and gene-silencing technologies has identified subunits and proposed regulators of SCF ubiquitin ligases as essential components of resistance (R)-gene-mediated resistance. Although no ubiquitin ligase targets that are associated with disease resistance have yet been identified in plants, there is evidence that this well-known protein-modification system may regulate plant defences against pathogens.
泛素化正成为一种常见的调控机制，可控制植物中的一系列细胞过程。几个实验室最近令人兴奋的发现表明，泛素化在植物抗病性中可能也起着重要作用。几种假定的泛素连接酶已被鉴定为防御调节因子。此外，遗传筛选和基因沉默技术的结合已确定SCF泛素连接酶的亚基和假定调节因子是抗性（R）基因介导的抗性的重要组成部分。虽然在植物中尚未鉴定出与抗病性相关的泛素连接酶靶标，但有证据表明，这种众所周知的蛋白质修饰系统可能调节植物对病原体的防御。
