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1
Element of caution: a case of reversible cytopenias associated with excessive zinc supplementation.注意事项:一例与过量补锌相关的可逆性血细胞减少症
CMAJ. 2003 Jul 22;169(2):129-31.
2
Excessive zinc ingestion. A reversible cause of sideroblastic anemia and bone marrow depression.锌摄入过量。铁粒幼细胞性贫血和骨髓抑制的一个可逆病因。
JAMA. 1990 Sep 19;264(11):1441-3. doi: 10.1001/jama.264.11.1441.
3
Zinc-induced anemia and neutropenia in an adolescent.一名青少年的锌诱导性贫血和中性粒细胞减少症。
J Pediatr. 2000 May;136(5):688-90. doi: 10.1067/mpd.2000.103355.
4
Zinc abuse and sideroblastic anemia.锌滥用与铁粒幼细胞性贫血。
Am J Hematol. 1993 Feb;42(2):227-8. doi: 10.1002/ajh.2830420217.
5
Excessive oral zinc supplementation.过量口服补锌
J Pediatr Hematol Oncol. 2002 Oct;24(7):582-4. doi: 10.1097/00043426-200210000-00020.
6
Unexplained anemia and neutropenia.不明原因的贫血和中性粒细胞减少症。
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7
Copper deficiency and sideroblastic anemia associated with zinc ingestion.与锌摄入相关的铜缺乏和铁粒幼细胞性贫血。
Am J Hematol. 1988 Jul;28(3):181-3. doi: 10.1002/ajh.2830280310.
8
Zinc-induced sideroblastic anemia: report of a case, review of the literature, and description of the hematologic syndrome.锌诱导的铁粒幼细胞贫血:1例报告、文献复习及血液学综合征描述
Am J Hematol. 1994 Jun;46(2):147-50. doi: 10.1002/ajh.2830460217.
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Zinc-induced copper deficiency: megamineral sideroblastic anemia.锌诱导的铜缺乏:巨矿物质铁粒幼细胞贫血。
Ann Intern Med. 1985 Sep;103(3):385-6. doi: 10.7326/0003-4819-103-3-385.
10
Zinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examination.锌诱导的铜缺乏症:三例最初通过骨髓检查确诊的病例报告。
Am J Clin Pathol. 2005 Jan;123(1):125-31. doi: 10.1309/v6gvyw2qtyd5c5pj.

引用本文的文献

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High-throughput genetic mapping discovers novel zinc toxicity response loci in .高通量基因定位发现了……中新型的锌毒性反应位点。 (原句结尾不完整)
bioRxiv. 2025 Jun 19:2025.06.12.659401. doi: 10.1101/2025.06.12.659401.
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Zinc-Containing Over-The-Counter Product Causing Sideroblastic Anemia and Neutropenia.含锌非处方产品导致铁粒幼细胞性贫血和中性粒细胞减少症。
Cureus. 2024 May 7;16(5):e59796. doi: 10.7759/cureus.59796. eCollection 2024 May.
3
Antiviral activity of zinc against hepatitis viruses: current status and future prospects.锌对肝炎病毒的抗病毒活性:现状与未来前景
Front Microbiol. 2023 Oct 16;14:1218654. doi: 10.3389/fmicb.2023.1218654. eCollection 2023.
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Clinical and genetic features of Japanese cases of MDS associated with VEXAS syndrome.MDS 相关 VEXAS 综合征日本病例的临床和遗传学特征。
Int J Hematol. 2023 Oct;118(4):494-502. doi: 10.1007/s12185-023-03598-8. Epub 2023 Apr 17.
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The Mechanisms of Zinc Action as a Potent Anti-Viral Agent: The Clinical Therapeutic Implication in COVID-19.锌作为一种强效抗病毒剂的作用机制:对新型冠状病毒肺炎的临床治疗意义。
Antioxidants (Basel). 2022 Sep 21;11(10):1862. doi: 10.3390/antiox11101862.
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Zinc Essentiality, Toxicity, and Its Bacterial Bioremediation: A Comprehensive Insight.锌的必需性、毒性及其细菌生物修复:全面洞察
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7
Enhanced Zinc Intake Protects against Oxidative Stress and Its Consequences in the Brain: A Study in an In Vivo Rat Model of Cadmium Exposure.摄入更多的锌可以预防大脑氧化应激及其后果:体内镉暴露大鼠模型的研究。
Nutrients. 2021 Jan 31;13(2):478. doi: 10.3390/nu13020478.
8
Cytopenia and Bone Marrow Dysplasia in a Case of Wilson's Disease.威尔逊病一例中的血细胞减少和骨髓发育异常
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9
The essential toxin: impact of zinc on human health.必需毒素:锌对人类健康的影响。
Int J Environ Res Public Health. 2010 Apr;7(4):1342-65. doi: 10.3390/ijerph7041342. Epub 2010 Mar 26.
10
Clonality investigation of morphologically dysplastic hematopoietic cells in myelodysplastic syndrome marrows.骨髓增生异常综合征骨髓中形态学发育异常造血细胞的克隆性研究。
Int J Hematol. 2008 Mar;87(2):176-183. doi: 10.1007/s12185-008-0038-y. Epub 2008 Feb 7.

本文引用的文献

1
Copper deficiency masquerading as myelodysplastic syndrome.伪装成骨髓增生异常综合征的铜缺乏症。
Blood. 2002 Aug 15;100(4):1493-5. doi: 10.1182/blood-2002-01-0256.
2
Case report of sideroblastic anemia caused by ingestion of coins.因吞食硬币导致铁粒幼细胞性贫血的病例报告。
Am J Hematol. 2001 Feb;66(2):126-9. doi: 10.1002/1096-8652(200102)66:2<126::AID-AJH1029>3.0.CO;2-J.
3
Zinc-induced copper deficiency in a coin swallower.吞食硬币者出现锌诱导的铜缺乏症。
Am J Gastroenterol. 2000 Oct;95(10):2975-7. doi: 10.1111/j.1572-0241.2000.02336.x.
4
Duration of symptoms and plasma cytokine levels in patients with the common cold treated with zinc acetate. A randomized, double-blind, placebo-controlled trial.用醋酸锌治疗的普通感冒患者的症状持续时间和血浆细胞因子水平。一项随机、双盲、安慰剂对照试验。
Ann Intern Med. 2000 Aug 15;133(4):245-52. doi: 10.7326/0003-4819-133-4-200008150-00006.
5
Zinc-induced anemia and neutropenia in an adolescent.一名青少年的锌诱导性贫血和中性粒细胞减少症。
J Pediatr. 2000 May;136(5):688-90. doi: 10.1067/mpd.2000.103355.
6
Copper intake and assessment of copper status.铜的摄入量及铜状态评估。
Am J Clin Nutr. 1998 May;67(5 Suppl):1041S-1045S. doi: 10.1093/ajcn/67.5.1041S.
7
Efficacy of zinc supplementation in reducing the incidence and prevalence of acute diarrhea--a community-based, double-blind, controlled trial.补充锌对降低急性腹泻发病率和患病率的疗效——一项基于社区的双盲对照试验。
Am J Clin Nutr. 1997 Aug;66(2):413-8. doi: 10.1093/ajcn/66.2.413.
8
Zinc toxicity following massive coin ingestion.大量吞食硬币后的锌中毒
Am J Forensic Med Pathol. 1997 Jun;18(2):148-53. doi: 10.1097/00000433-199706000-00008.
9
Treatment of four siblings with progressive myoclonus epilepsy of the Unverricht-Lundborg type with N-acetylcysteine.用N-乙酰半胱氨酸治疗四名患有翁韦里希特-伦德伯格型进行性肌阵挛癫痫的兄弟姐妹。
Neurology. 1996 Nov;47(5):1264-8. doi: 10.1212/wnl.47.5.1264.
10
Zinc-induced sideroblastic anemia: report of a case, review of the literature, and description of the hematologic syndrome.锌诱导的铁粒幼细胞贫血:1例报告、文献复习及血液学综合征描述
Am J Hematol. 1994 Jun;46(2):147-50. doi: 10.1002/ajh.2830460217.

注意事项:一例与过量补锌相关的可逆性血细胞减少症

Element of caution: a case of reversible cytopenias associated with excessive zinc supplementation.

作者信息

Irving Julie A, Mattman Andre, Lockitch Gillian, Farrell Kevin, Wadsworth Louis D

机构信息

Department of Pathology and Laboratory Medicine, Children's and Women's Health Centre of British Columbia and the University of British Columbia, Vancouver, BC.

出版信息

CMAJ. 2003 Jul 22;169(2):129-31.

PMID:12874162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC164980/
Abstract

Zinc is a common supplement and is widely available as a standard component of many over-the-counter products. A number of reports have identified an association between excessive zinc intake and severe cytopenia. We report a case of zinc-induced copper deficiency in a young adult to illustrate this under-recognized cause of anemia and neutropenia.

摘要

锌是一种常见的补充剂,作为许多非处方产品的标准成分广泛可得。许多报告已确定过量摄入锌与严重血细胞减少之间存在关联。我们报告一例年轻成人锌诱导铜缺乏的病例,以说明这种未得到充分认识的贫血和中性粒细胞减少的病因。