Lazzaroni F, Bonassi S, Magnani M, Puglisi P, Salomone P, Pantarotto F, Mazzeo P, Cotelessa G, Norelli M T, Santi F
Istituto di Puericultura e Medicina Neonatale, Università degli Studi di Genova.
Minerva Pediatr. 1992 Oct;44(10):511-7.
A cross-sectional study was conducted on 2415 mother/newborn pairs, in order to evaluate the relationship between maternal alcohol consumption and birth weight. The results of this study are consistent with previous reports, that pointed out the casual relationship between maternal drinking during pregnancy, and reduction in birth weight. This reduction was evident only on the subset of smokers. A further stratification by the sex of newborn, showed a heavier effect on male newborns, who experienced a significant reduction of 6.2 grams in birth weight for each g of absolute alcohol consumed daily during pregnancy by mother. The findings of this study support the evidence of neonatal functional damages due to alcohol, even at very low doses. A strong increase of early jaundice were found among the outcome of exposed women (OD = 3.30; 95% CI 1.03-10.54).
对2415对母婴进行了一项横断面研究，以评估母亲饮酒与出生体重之间的关系。该研究结果与之前的报告一致，之前的报告指出孕期母亲饮酒与出生体重降低之间存在因果关系。这种降低仅在吸烟的子集中明显。按新生儿性别进一步分层显示，对男性新生儿的影响更大，母亲在孕期每天每摄入1克纯酒精，男性新生儿出生体重就会显著降低6.2克。该研究结果支持了即使在极低剂量下酒精也会对新生儿造成功能损害的证据。在暴露组女性的结果中发现早期黄疸大幅增加（比值比=3.30；95%置信区间1.03-10.54）。
