Jaddoe Vincent W V, Bakker Rachel, Hofman Albert, Mackenbach Johan P, Moll Henriëtte A, Steegers Eric A P, Witteman Jacqueline C M
Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands.
Ann Epidemiol. 2007 Oct;17(10):834-40. doi: 10.1016/j.annepidem.2007.04.001. Epub 2007 Jun 28.
To examine the associations of alcohol consumption in different periods of pregnancy with the risks of low birth weight and preterm birth.
This study was based on 7141 subjects participating in a population-based prospective cohort study from early pregnancy. Alcohol consumption was assessed in early, mid, and late pregnancy. Birth outcomes were birth weight in grams, low birth weight (<2500 g), small size for gestational age at birth (< -2 standard deviation scores) and preterm birth (gestational age <37 weeks).
Overall, alcohol consumption during pregnancy was not associated with adverse birth outcomes. However, dose-response analyses showed tendencies toward adverse effects of average consumption of 1 or more alcoholic drinks per day in early pregnancy on birth weight (difference -129 g [95% confidence interval (CI): -271, 12]), low birth weight (adjusted odds ratio [aOR] 4.81 [95% CI: 1.10, 21.08]), small size for gestational age at birth (aOR 1.45 [95% CI: 0.33, 6.44]) and preterm birth (aOR 2.51 [95% CI: 0.92, 6.81]). Similar effects were found in late pregnancy.
Average consumption of one or more but not less than one alcoholic drink per day in early or late pregnancy seems to be associated with adverse birth outcomes in the offspring.
研究孕期不同阶段饮酒与低出生体重和早产风险之间的关联。
本研究基于7141名从孕早期开始参与一项基于人群的前瞻性队列研究的受试者。在孕早期、中期和晚期评估饮酒情况。出生结局包括以克为单位的出生体重、低出生体重（<2500克）、出生时小于胎龄（< -2标准差分数）和早产（孕周<37周）。
总体而言，孕期饮酒与不良出生结局无关。然而，剂量反应分析显示，孕早期每天平均饮用1杯或更多酒精饮料对出生体重（差异-129克[95%置信区间（CI）：-271, 12]）、低出生体重（调整优势比[aOR] 4.81 [95% CI：1.10, 21.08]）、出生时小于胎龄（aOR 1.45 [95% CI：0.33, 6.44]）和早产（aOR 2.51 [95% CI：0.92, 6.81]）有不良影响的趋势。在孕晚期也发现了类似的影响。
孕早期或晚期每天平均饮用1杯或更多但不少于1杯酒精饮料似乎与后代的不良出生结局有关。
