Horoupian Dikran S, Hattab Eyas M, Heit Gary
Department of Pathology, Stanford University Medical Center, CA 94305, USA.
Hum Pathol. 2003 Jul;34(7):714-6. doi: 10.1016/s0046-8177(03)00182-5.
A 17-year-old woman with intractable seizures since infancy underwent resection of an epileptic focus in the left frontal cortex. The cytoplasm of many cortical astrocytes contained amorphous eosinophilic inclusions, which ultrastructurally were non-membrane bound and consisted of densely packed osmiophilic material. Similar inclusions have previously been observed, at autopsy, in patients with unspecified mental retardation and various brain malformations. The present report is unique in that the inclusions were detected in the resected specimen of an epileptic focus. The patient is neurologically intact except for the seizures that presently are totally controlled by the surgery. The pathogenesis of these inclusions is unclear. The fact they occurred in an epileptic focus raises the possibility that prolonged seizures or its underlying precipitating factors may cause conglutination of an indeterminate element of the protoplasmic astrocytes resulting in inclusion formation.
一名自婴儿期起就患有顽固性癫痫的17岁女性接受了左侧额叶皮质癫痫病灶切除术。许多皮质星形胶质细胞的细胞质中含有无定形嗜酸性包涵体，超微结构显示这些包涵体无膜包裹，由密集堆积的嗜锇物质组成。此前在尸检中，在患有未明确诊断的智力发育迟缓及各种脑畸形的患者中也观察到了类似的包涵体。本报告的独特之处在于，这些包涵体是在癫痫病灶的切除标本中检测到的。除了癫痫发作外，该患者神经功能完好，目前癫痫发作已通过手术得到完全控制。这些包涵体的发病机制尚不清楚。它们出现在癫痫病灶中的这一事实增加了一种可能性，即长时间的癫痫发作或其潜在的诱发因素可能导致原浆性星形胶质细胞的某种不确定成分发生凝集，从而形成包涵体
