Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Neurology. 2013 Jul 16;81(3):e14-6. doi: 10.1212/WNL.0b013e31829bfe54.
Astrocytic dysfunction is implicated in epilepsy through many proposed molecular mechanisms, but there is also a clinicopathologic entity of epilepsy featuring astrocytic inclusions. At least 17 cases of early-onset epilepsy with eosinophilic, hyaline astrocytic inclusions have been reported since the early 1990s. Most of these cases also involve developmental delay. The diagnosis is made by neuropathologic analysis that demonstrates brightly eosinophilic, hyaline, refractile astrocytic inclusions seen under light microscopy with hematoxylin & eosin stain. We review the clinicopathologic entity of pediatric epilepsy with hyaline astrocytic inclusions and report an illustrative case.
星形胶质细胞功能障碍通过许多提出的分子机制与癫痫有关，但也有一种以星形胶质细胞包涵体为特征的临床病理实体的癫痫。自 20 世纪 90 年代初以来，已经报道了至少 17 例早发性癫痫伴嗜酸性、玻璃样星形胶质细胞包涵体。这些病例大多还伴有发育迟缓。诊断是通过神经病理学分析做出的，该分析显示在苏木精和伊红染色的光学显微镜下可见明亮的嗜酸性、玻璃样、折射性星形胶质细胞包涵体。我们回顾了伴有玻璃样星形胶质细胞包涵体的儿童癫痫的临床病理实体，并报告了一个说明性病例。
