Minagawa M, Shioda K, Shimizu Y, Isshiki T
Department of Neuropsychiatry, Saitama Medical School, Japan.
Acta Neuropathol. 1992;84(1):113-6. doi: 10.1007/BF00427225.
A unique pathological finding of astrocytes was observed in the brain of a 20-year-old man who had severe physical and mental retardation. The brain was malformed showing micropolygyria in several cortical areas. A large number of hypertrophic astrocytes with eosinophilic granular substances in their cytoplasm were found throughout the cerebral cortex. Several staining procedures and electron microscopical examinations were carried out on these intracytoplasmic inclusion. It was found that the appearance and staining character of these inclusions were different from other astrocytic changes, especially the Rosenthal fiber, described so far. The authors consider that these inclusion bodies in cerebral cortical astrocytes represent new pathological changes of astrocytes that appear to be associated with malformation of the brain.
在一名患有严重身心发育迟缓的20岁男性大脑中观察到星形胶质细胞独特的病理表现。大脑畸形，在几个皮质区域呈现微小多脑回。在整个大脑皮质发现大量细胞质内含有嗜酸性颗粒物质的肥大星形胶质细胞。对这些胞质内包涵体进行了几种染色程序和电子显微镜检查。发现这些包涵体的外观和染色特征与迄今描述的其他星形胶质细胞变化，尤其是罗森塔尔纤维不同。作者认为，大脑皮质星形胶质细胞中的这些包涵体代表了星形胶质细胞的新病理变化，似乎与大脑畸形有关。
