Nurnberger John I, Foroud Tatiana, Flury Leah, Meyer Eric T, Wiegand Ryan
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Alcohol Res Health. 2002;26(3):233-40.
The Collaborative Study on the Genetics of Alcoholism (COGA) seeks to identify genes contributing to alcoholism and related traits (i.e., phenotypes), including depression. Among alcoholic subjects the COGA study found an increased prevalence of depressive syndrome (i.e., depression that may or may not occur in conjunction with increased drinking). This combination of alcoholism and depression tends to run in families. Comorbid alcoholism and depression occurred substantially more often in first-degree relatives of COGA participants with alcoholism than in relatives of control participants. Based on these data, COGA investigators defined three phenotypes--"alcoholism," "alcoholism and depression," and "alcoholism or depression"--and analyzed whether these phenotypes were linked to specific chromosomal regions. These analyses found that the "alcoholism or depression" phenotype showed significant evidence for genetic linkage to an area on chromosome 1. This suggests that a gene or genes on chromosome 1 may predispose some people to alcoholism and others to depression (which may be alcohol induced).
酗酒遗传学合作研究（COGA）旨在确定导致酗酒及相关特征（即表型）的基因，这些特征包括抑郁症。在酗酒受试者中，COGA研究发现抑郁综合征（即可能与饮酒增加相关或无关的抑郁症）的患病率有所上升。酗酒与抑郁症的这种组合往往在家族中出现。与对照组参与者的亲属相比，COGA研究中患有酗酒症的参与者的一级亲属中，酗酒与抑郁症共病的情况要多得多。基于这些数据，COGA研究人员定义了三种表型——“酗酒”、“酗酒与抑郁症”和“酗酒或抑郁症”——并分析了这些表型是否与特定的染色体区域相关联。这些分析发现，“酗酒或抑郁症”表型显示出与1号染色体上一个区域存在显著基因连锁的证据。这表明1号染色体上的一个或多个基因可能使一些人易患酗酒症，而另一些人易患抑郁症（可能由酒精诱发）。
