Bucholz K K, Cadoret R, Cloninger C R, Dinwiddie S H, Hesselbrock V M, Nurnberger J I, Reich T, Schmidt I, Schuckit M A
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri 63110-1093.
J Stud Alcohol. 1994 Mar;55(2):149-58. doi: 10.15288/jsa.1994.55.149.
Within- and cross-center test-retest studies were conducted to study the reliability of a new, semistructured, comprehensive, polydiagnostic psychiatric interview being used in a multisite genetic linkage study of alcoholism. Findings from both studies indicated that reliability for the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) was high for DSM-III-R substance dependence disorders, but less so for substance abuse disorders. Reliability of depression was good in both studies, but mixed for antisocial personality disorder (ASP). Findings are presented in terms of specific substance dependence and abuse diagnoses, as well as for depression and ASP. Criterion-specific reliabilities are examined by type of substance used. Although SSAGA was designed to provide for broad phenotyping of alcoholism, review of its new features suggests its suitability for a variety of family studies, not just those focusing on substance abuse.
开展了中心内和跨中心的重测研究，以研究一种新的、半结构化、综合性、多诊断性精神科访谈在酒精中毒多部位基因连锁研究中的可靠性。两项研究的结果均表明，酒精中毒遗传学半结构化评估（SSAGA）对DSM-III-R物质依赖障碍的可靠性较高，但对物质滥用障碍的可靠性较低。两项研究中抑郁症的可靠性良好，但反社会人格障碍（ASP）的可靠性不一。研究结果以特定的物质依赖和滥用诊断以及抑郁症和反社会人格障碍呈现。按使用的物质类型检查特定标准的可靠性。尽管SSAGA旨在提供酒精中毒的广泛表型分析，但其新特征的回顾表明它适用于各种家庭研究，而不仅仅是那些专注于物质滥用的研究。
