Moriyama Hiroyoshi, Iizuka Tohru, Nagai Masahiro, Miyataka Hideki, Satoh Toshio
Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Yakugaku Zasshi. 2003 Jul;123(7):607-11. doi: 10.1248/yakushi.123.607.
Antiinflammatory activities of heat-treated Cassia alata leaf extract and kaempferol 3-O-gentiobioside (K3G) isolated from C. alata as an abundant flavonoid glycoside were studied by comparing their activities with the activities of sun-dried C. alata leaf extract. We observed strong inhibitory effects on Concanavalin A-induced histamine release from rat peritoneal exudate cells both in the extracts of heat-treated and sun-dried C. alata leaves. Furthermore, the heat-treated leaf extract exhibited stronger inhibitory effects than the effects of the sun-dried leaf extract at low concentrations in the studies of Concanavalin A-induced histamine release, 5-lipoxygenase inhibition, and also inhibition of cyclooxygenases (COX-1 and COX-2), whereas K3G showed weak inhibitory effects on Concanavalin A-induced histamine release, 5-lipoxygenase, and COX-1. No anti-hyaluronidase effect was detected in any of the materials tested.
研究了热处理决明叶提取物和从决明中分离出的丰富黄酮苷山奈酚3 - O -龙胆二糖苷（K3G）的抗炎活性，并将它们的活性与晒干的决明叶提取物的活性进行比较。我们观察到，热处理和晒干的决明叶提取物对伴刀豆球蛋白A诱导的大鼠腹腔渗出细胞组胺释放均有强烈抑制作用。此外，在伴刀豆球蛋白A诱导的组胺释放、5 - 脂氧合酶抑制以及环氧化酶（COX - 1和COX - 2）抑制研究中，热处理叶提取物在低浓度时比晒干叶提取物表现出更强的抑制作用，而K3G对伴刀豆球蛋白A诱导的组胺释放、5 - 脂氧合酶和COX - 1表现出较弱的抑制作用。在所测试的任何材料中均未检测到抗透明质酸酶作用。
