Ochi Mariko, Sono Shin, Sei Hiroyoshi, Oishi Katsutaka, Kobayashi Hisato, Morita Yusuke, Ishida Norio
Department of Integrative Physiology, School of Medicine, The University of Tokushima, Kuramoto, 770-8503, Tokushima, Japan.
Neurosci Lett. 2003 Aug 28;347(3):163-6. doi: 10.1016/s0304-3940(03)00688-8.
The period of circadian rhythm remains remarkably stable in both sexes under conditions of constant darkness. Several studies have indicated that gonadal hormones such as estradiol shorten the period of circadian rhythms. We observed that the free-running period of core body temperature is longer in male homozygous Clock mutant mice than in females, although this difference is not found in wild mice. Furthermore, a gonadectomy had no effect on the period of core body temperature in either sex. This suggests the existence of a sex-related difference of the mammalian circadian system, and that it is independent of peripheral gonadal regulations.
在持续黑暗条件下，昼夜节律周期在两性中都保持着显著的稳定性。多项研究表明，诸如雌二醇等性腺激素会缩短昼夜节律的周期。我们观察到，雄性纯合Clock突变小鼠的核心体温自由运转周期比雌性小鼠长，尽管在野生小鼠中未发现这种差异。此外，去势对两性的核心体温周期均无影响。这表明哺乳动物昼夜节律系统存在性别相关差异，且该差异独立于外周性腺调节。
