振荡感知：小鼠昼夜节律系统中CLOCK蛋白的起伏
Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system.
作者信息
Debruyne Jason P
机构信息
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
出版信息
J Genet. 2008 Dec;87(5):437-46. doi: 10.1007/s12041-008-0066-7.
Abstract
A functional mouse CLOCK protein has long been thought to be essential for mammalian circadian clockwork function, based mainly on studies of mice bearing a dominant negative, antimorphic mutation in the Clock gene. However, new discoveries using recently developed Clock-null mutant mice have shaken up this view. In this review, I discuss how this recent work impacts and alters the previous view of the role of CLOCK in the mouse circadian clockwork.
摘要
长期以来，人们一直认为功能性小鼠CLOCK蛋白对于哺乳动物生物钟功能至关重要，这主要基于对Clock基因携带显性负性、反式突变的小鼠的研究。然而，最近利用新培育出的Clock基因敲除突变小鼠所做的发现动摇了这一观点。在这篇综述中，我将讨论这项最新研究如何影响并改变了之前关于CLOCK在小鼠生物钟机制中作用的观点。
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