Zebrowska-Lupina I, Ossowska G, Klenk-Majewska B
Department of Pharmacology, Medical School, Lublin, Poland.
Pharmacol Biochem Behav. 1991 Jun;39(2):293-6. doi: 10.1016/0091-3057(91)90182-2.
The effect of chronic stress (14 various unpredictable stressors over 16 days) on electric footshock-induced fighting behavior of pairs of male Wistar rats was studied. The influence of antidepressant drugs (imipramine, desmethylimipramine, nomifensine, clomipramine, mianserine and doxepine) administered chronically (1 h before the stressor) on the aggressive behavior was also investigated in control and in stressed rats. Moreover, the effect of chronic stress on noradrenaline (NA) utilization in the brain was estimated in control and in antidepressant-treated rats. It was demonstrated that, in rats submitted to repeated unpredictable stress, the fighting behavior was significantly reduced 48 and 72 h after the last stressor. NA utilization in the brain was decreased 72 h after the stress termination. Prolonged treatment with antidepressant drugs restored the intensity of fighting behavior in stressed rats to control value as well as normalized NA utilization in the brain. It is suggested that antidepressant drugs may counteract the affective aggression deficit induced by chronic stress.
研究了慢性应激（16天内14种不同的不可预测应激源）对雄性Wistar大鼠成对电击诱发打斗行为的影响。还在对照大鼠和应激大鼠中研究了长期（在应激源前1小时）给予抗抑郁药（丙咪嗪、去甲丙咪嗪、诺米芬辛、氯米帕明、米安色林和多塞平）对攻击行为的影响。此外，在对照大鼠和接受抗抑郁药治疗的大鼠中评估了慢性应激对大脑中去甲肾上腺素（NA）利用的影响。结果表明，在经历反复不可预测应激的大鼠中，最后一次应激源后48小时和72小时，打斗行为显著减少。应激终止72小时后，大脑中NA的利用减少。长期使用抗抑郁药治疗可将应激大鼠的打斗行为强度恢复到对照值，并使大脑中NA的利用正常化。提示抗抑郁药可能抵消慢性应激诱导的情感性攻击缺陷。
